Buss L, Tolstrup J, Munk C, Bergholt T, Ottesen B, Grønbaek M, Kjaer S K
Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Acta Obstet Gynecol Scand. 2006;85(4):467-75. doi: 10.1080/00016340500494887.
To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion.
We used interview data from a population-based prospective cohort study comprising 11,088 women and data from a linkage of the cohort with the Hospital Discharge Register to compare spontaneous abortions as reported in the interview with those identified in the register. Based on interview data, we estimated the rate of spontaneous abortion during the two-year follow-up. Finally, risk determinants for incident spontaneous abortion were analyzed by means of logistic regression.
A total of 654 spontaneous abortions before enrolment in the study were reported by the women compared to 531 abortions found in the register. More than 80% of the spontaneous abortions identified from both sources were recorded in the same year. During follow-up a total of 20.9% of pregnancies intended to be carried to term ended as a spontaneous abortion. In the risk factor analysis, we found that previous spontaneous abortion, being single, never having used oral contraceptives, and use of intrauterine device were associated with increased risk of subsequent spontaneous abortion. In addition, it was indicated that a short interpregnancy interval following a spontaneous abortion may confer an increased risk of abortion in the subsequent pregnancy.
We found a high rate of spontaneous abortion in the present study and an acceptable agreement between information obtained by interview and register information. More than 25% of the spontaneous abortions were only reported by the women, and this could not be explained by erroneously reported induced abortions, and may be early, nonhospitalized abortions. We confirm that number of previous spontaneous abortions is a strong determinant, and our data may also indicate a role of previous contraceptive habits. A role of the length of interpregnancy interval in the risk of spontaneous abortion cannot be ruled out.
通过比较两种不同的数据来源来评估自然流产的发生率。估计两年期间自然流产的发生率，并检查新发自然流产风险的潜在预测因素。
我们使用了一项基于人群的前瞻性队列研究中的访谈数据，该研究包括11,088名女性，以及该队列与医院出院登记处的关联数据，以比较访谈中报告的自然流产与登记处确定的自然流产情况。基于访谈数据，我们估计了两年随访期间的自然流产发生率。最后，通过逻辑回归分析新发自然流产的风险决定因素。
女性报告在研究入组前共有654例自然流产，而登记处发现531例流产。来自这两个来源的自然流产中，超过80%记录在同一年。在随访期间，共有20.9%打算足月分娩的妊娠以自然流产告终。在风险因素分析中，我们发现既往自然流产、单身、从未使用过口服避孕药以及使用宫内节育器与随后自然流产风险增加有关。此外，有迹象表明自然流产后较短的妊娠间隔可能会使随后妊娠的流产风险增加。
我们在本研究中发现自然流产发生率较高，访谈获得的信息与登记信息之间的一致性尚可。超过25%的自然流产仅由女性报告，这无法用错误报告的人工流产来解释，可能是早期的、未住院的流产。我们证实既往自然流产次数是一个重要的决定因素，我们的数据也可能表明既往避孕习惯的作用。不能排除妊娠间隔长度在自然流产风险中的作用。
