全血呈现由红细胞诱导的血小板侧向运动的计算模型。
Computational model of whole blood exhibiting lateral platelet motion induced by red blood cells.
作者信息
Crowl Lindsay M, Fogelson Aaron L
出版信息
Int J Numer Method Biomed Eng. 2010 Mar 1;26(3-4):471-487. doi: 10.1002/cnm.1274.
Abstract
An Immersed Boundary method is developed in which the fluid's motion is calculated using the lattice Boltzmann method. The method is applied to explore the experimentally-observed lateral redistribution of platelets and platelet-sized particles in concentrated suspensions of red blood cells undergoing channel flow. Simulations capture red-blood-cell-induced lateral platelet motion and the consequent development of a platelet concentration profile that includes an enhanced concentration within a few microns of the channel walls. In the simulations, the near-wall enhanced concentration develops within approximately 400 msec starting from a random distribution of red blood cells and a uniform distribution of platelet-sized particles.
摘要
开发了一种浸入边界方法，其中使用格子玻尔兹曼方法计算流体的运动。该方法用于探究在经历通道流动的红细胞浓缩悬浮液中，通过实验观察到的血小板和血小板大小颗粒的横向重新分布。模拟捕捉了红细胞诱导的血小板横向运动以及随之产生的血小板浓度分布的发展情况，该分布包括通道壁几微米范围内浓度的增强。在模拟中，从红细胞的随机分布和血小板大小颗粒的均匀分布开始，近壁增强浓度在大约400毫秒内形成。
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