Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap 2-Dong, Songpa-Gu, Seoul, Republic of Korea.
Osteoporos Int. 2011 Nov;22(11):2837-46. doi: 10.1007/s00198-010-1504-y. Epub 2010 Dec 9.
The association between serum osteocalcin levels and metabolic syndrome (MS) in Korean individuals was investigated. Serum osteocalcin levels are significantly lower in subjects with MS than in those without the disease, regardless of glucose metabolism.
Osteocalcin was recently shown to affect energy metabolism. In the present study, we investigated the possible association between serum osteocalcin concentrations and MS.
A cross-sectional community-based survey was conducted. Serum osteocalcin, type 1 collagen C-telopeptide (CTX) and total alkaline phosphatase (ALP) concentrations were determined in 567 subjects. MS was defined according to NCEP-ATP III criteria.
Serum osteocalcin concentrations were significantly lower in subjects with MS than those without MS in postmenopausal women (18.923 ± 7.685 vs 22.513 ± 7.344 ng/ml, P<0.001) and marginally lower in subjects with MS than those without MS in men (14.550 ± 5.090 vs 16.125 ± 4.749 ng/ml, P=0.086) after adjustment for age and BMI. Further controlling with CTX or ALP did not affect this association in postmenopausal women; however, controlling with osteocalcin abolished the association between CTX and MS. Significant differences in serum osteocalcin levels by MS status were noted in subjects with normal glucose tolerance as well as those with abnormal glucose tolerance (P=0.032 and P<0.001, respectively). Compared with subjects with the highest quartile of osteocalcin, those in the lower quartile groups (Q1-Q3) had significantly increased risks of MS (ORs=5.18, CIs=1.15-23.42) in men. In postmenopausal women, the ORs for MS were significantly higher in the lowest quartile than in the highest quartile (ORs=5.25, CIs=2.42-11.36).
These findings suggest that osteocalcin is associated with MS, independently of glucose metabolism.
研究血清骨钙素水平与韩国人群代谢综合征（MS）之间的关系。无论葡萄糖代谢如何，患有 MS 的受试者的血清骨钙素水平明显低于无该疾病的受试者。
骨钙素最近被证明会影响能量代谢。在本研究中，我们调查了血清骨钙素浓度与 MS 之间可能存在的关联。
进行了一项基于社区的横断面研究。在 567 名受试者中测定了血清骨钙素、Ⅰ型胶原 C 端肽（CTX）和总碱性磷酸酶（ALP）浓度。根据 NCEP-ATP III 标准定义 MS。
在绝经后妇女中，患有 MS 的受试者的血清骨钙素浓度明显低于无 MS 的受试者（18.923±7.685 与 22.513±7.344 ng/ml，P<0.001），在男性中，患有 MS 的受试者的血清骨钙素浓度略低于无 MS 的受试者（14.550±5.090 与 16.125±4.749 ng/ml，P=0.086），调整年龄和 BMI 后。在绝经后妇女中，进一步控制 CTX 或 ALP 并不能影响这种关联；然而，控制骨钙素则消除了 CTX 与 MS 之间的关联。在葡萄糖耐量正常和葡萄糖耐量异常的受试者中，根据 MS 状态观察到血清骨钙素水平的显著差异（P=0.032 和 P<0.001）。与骨钙素最高四分位数组相比，男性骨钙素最低四分位数组（Q1-Q3）发生 MS 的风险显著增加（ORs=5.18，95%CI=1.15-23.42）。在绝经后妇女中，最低四分位数的 MS 发生率明显高于最高四分位数（ORs=5.25，95%CI=2.42-11.36）。
这些发现表明，骨钙素与 MS 相关，独立于葡萄糖代谢。
