School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia.
Eur J Endocrinol. 2010 Aug;163(2):265-72. doi: 10.1530/EJE-10-0414. Epub 2010 May 25.
Bone-derived undercarboxylated osteocalcin regulates insulin secretion and sensitivity in mice, and reduced serum total osteocalcin (TOC) is associated with diabetes in humans. However, the relationship between TOC levels and other cardiovascular risk factors is uncertain. We sought to determine whether serum TOC is associated with metabolic syndrome and its components in older men.
Cross-sectional analysis from a population-based cohort of men aged >or=70 years.
Early morning sera were assayed for TOC. Insulin resistance was estimated using a homeostatic model (HOMA2-IR). Metabolic syndrome was defined according to NCEP-ATPIII criteria.
TOC was assayed in 4047 men. Men who were not fasting and reported having bone fractures, Paget's disease, or bisphosphonate, glucocorticoid, or warfarin use were excluded, leaving 2765 men with metabolic syndrome present in 797 (28.8%). TOC was inversely associated with waist circumference, glucose, and triglyceride levels and HOMA2-IR (all P<0.001), and was lower in men with metabolic syndrome (mean+/-S.E.M.: 20.1+/-0.4 vs 21.4+/-0.2 microg/l, P=0.002). In multivariate analysis, men with TOC of 13.25-16.55 and <13.25 microg/l had 1.5- to 2-fold increased risk of metabolic syndrome compared with men with levels >or=30 microg/l. TOC remained associated with metabolic syndrome after adjustment for individual components, but not after adjusting for both waist circumference and glucose.
Increased waist circumference, reduced TOC, elevated glucose, and triglyceride levels are inter-related in aging men. Osteocalcin may lie in the causal pathway between central adiposity and insulin resistance. Further research is required to evaluate whether interventions which raise osteocalcin levels might decrease cardiovascular risk.
骨源未羧化骨钙素可调节小鼠胰岛素的分泌和敏感性，且血清总骨钙素（TOC）降低与人类糖尿病相关。然而，TOC 水平与其他心血管危险因素之间的关系尚不确定。我们旨在确定老年男性血清 TOC 是否与代谢综合征及其成分有关。
一项基于人群的 70 岁以上男性队列的横断面分析。
检测清晨血清 TOC。使用稳态模型（HOMA2-IR）估计胰岛素抵抗。根据 NCEP-ATPIII 标准定义代谢综合征。
共检测了 4047 名男性。排除未禁食且报告有骨折、佩吉特病、双膦酸盐、糖皮质激素或华法林使用者后，有 2765 名男性存在代谢综合征（797 例，28.8%）。TOC 与腰围、血糖和甘油三酯水平及 HOMA2-IR 呈负相关（均 P<0.001），且在代谢综合征男性中较低（均值+/-S.E.M.：20.1+/-0.4 比 21.4+/-0.2μg/l，P=0.002）。多变量分析显示，与 TOC 水平>or=30μg/l 的男性相比，TOC 为 13.25-16.55 和<13.25μg/l 的男性患代谢综合征的风险增加 1.5-2 倍。TOC 在调整单个成分后仍与代谢综合征相关，但在调整腰围和血糖后则不然。
在老年男性中，腰围增加、TOC 降低、血糖和甘油三酯水平升高相互关联。骨钙素可能位于中心性肥胖和胰岛素抵抗之间的因果途径中。需要进一步研究以评估提高骨钙素水平是否可以降低心血管风险。
