马达加斯加马鲁兰布区学龄儿童曼氏血吸虫感染负担沉重。
High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar.
作者信息
Spencer Stephen A, Penney James M St John, Russell Hannah J, Howe Anthony P, Linder Cortland, Rakotomampianina Andriamahitsisambatra L D, Nandimbiniaina Anjara M, Squire S Bertel, Stothard J Russell, Bustinduy Amaya L, Rahetilahy Alain M
机构信息
Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
The University of Manchester Medical School, Manchester, UK.
出版信息
Parasit Vectors. 2017 Jun 24;10(1):307. doi: 10.1186/s13071-017-2249-7.
BACKGROUND
A school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.
METHODS
School-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study.
RESULTS
Of 399 school-aged children screened, 93.7% were infected with S. mansoni based on CCA analysis. Kato-Katz analysis of stool revealed S. mansoni infection in 73.6% (215/ 292). Heavy infections (> 400 eggs per gram) were common (32.1%; 69/ 215), with a mean of 482 eggs per gram of stool. Moderate infection intensities were detected in 31.2% (67/ 215) and light infection intensities in 36.7% (79/ 215) of infected participants. No infection with S. haematobium was detected by urine filtration.
CONCLUSIONS
Intestinal schistosomiasis appears a considerable public health issue in this remote area of Madagascar where there is a pressing need for mass drug administration.
背景
开展了一项基于学校的调查，以评估马达加斯加马鲁兰博区学龄儿童血吸虫病的流行率和感染强度。
方法
从六所经特意挑选的学校中选取学龄儿童，通过尿液过滤检测埃及血吸虫感染情况，采用循环阴极抗原（CCA）和加藤厚涂片粪便分析法检测曼氏血吸虫感染情况。本研究中，研究人员未对土壤传播的蠕虫（STH）进行检测。
结果
在399名接受筛查的学龄儿童中，基于CCA分析，93.7%的儿童感染了曼氏血吸虫。粪便的加藤厚涂片分析显示，73.6%（215/292）的儿童感染了曼氏血吸虫。重度感染（每克粪便中虫卵>400个）较为常见（32.1%；69/215），粪便中虫卵的平均含量为每克482个。在31.2%（67/215）的受感染参与者中检测到中度感染强度，在36.7%（79/215）的受感染参与者中检测到轻度感染强度。尿液过滤未检测到埃及血吸虫感染。
结论
在马达加斯加的这个偏远地区，肠道血吸虫病似乎是一个相当严重的公共卫生问题，迫切需要开展大规模药物治疗。
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