Plk1 的底物，超越了有丝分裂中的功能。
The substrates of Plk1, beyond the functions in mitosis.
机构信息
Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
Protein Cell. 2010 Nov;1(11):999-1010. doi: 10.1007/s13238-010-0131-x. Epub 2010 Dec 10.
Abstract
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.
摘要
丝氨酸/苏氨酸激酶 1（Plk1）是真核细胞细胞分裂的关键调节因子。在这篇简短的综述中，我们简要总结了 Plk1 在有丝分裂过程中调节的已确立功能。除了有丝分裂，我们主要关注 Plk1 作为关键参与者出现的意外过程，包括微管动力学、DNA 复制、染色体动力学、p53 调节和从 G2 DNA 损伤检查点恢复。我们的讨论主要基于在这些细胞事件中 Plk1 靶向的关键底物以及与每个磷酸化事件相关的功能意义。
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2
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