Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
Eur J Appl Physiol. 2011 Jul;111(7):1369-79. doi: 10.1007/s00421-010-1766-2. Epub 2010 Dec 14.
The purpose of the study was to examine predictors of the leg hemodynamic response to exercise in middle- and older-aged men and women. Femoral artery blood flow (FBF), mean arterial pressure (MAP), and femoral vascular conductance (FVC, calculated as the quotient of FBF and MAP) were measured at rest and during 5 min of single knee-extensor exercise at ~10 W workload in healthy men (n = 31) and women (n = 32) (age 40-72 years). Age, menopausal status, maximal quadriceps strength, blood lipids, vitamin D levels, maximal oxygen uptake (VO(2max)), physical activity, blood pressure, estimated quadriceps muscle mass, and body mass index (BMI) were also assessed. The effect of age on FBF and FVC was negative and significant in men (r = -0.44 and -0.42 and p = 0.01 and 0.02, respectively) but was abolished by normalization to estimated quadriceps muscle (p = 0.18 and 0.73, respectively). There was no effect of age on leg hemodynamic responses to exercise in women (alone or normalized to quadriceps muscle), but menopausal status was a significant predictor of FVC and normalized FVC (p = 0.04 and 0.02, respectively). The multivariate model for exercising FVC in men (in order of strongest to weakest predictors) included quadriceps strength, BMI, resting FVC, age, and high-density lipoprotein cholesterol. The multivariate model for exercising FVC in women included quadriceps mass, systolic blood pressure, vitamin D, age, VO(2max), waist circumference, and physical activity score. These findings suggest that factors besides chronological age mediate exercising leg hemodynamics in middle-aged to older adults and that these factors are sex-specific.
这项研究的目的是检验中年和老年男性和女性腿部血液动力学对运动反应的预测因素。在健康男性（n=31）和女性（n=32）中，分别测量了休息时和 5 分钟单膝伸肌运动（约 10 W 工作量）时股动脉血流（FBF）、平均动脉压（MAP）和股血管传导性（FVC，计算为 FBF 与 MAP 的商）。还评估了年龄、绝经状态、最大股四头肌力量、血脂、维生素 D 水平、最大摄氧量（VO（2max））、身体活动、血压、估计的股四头肌肌肉量和体重指数（BMI）。年龄对男性 FBF 和 FVC 的影响为负且显著（r=-0.44 和-0.42，p=0.01 和 0.02），但通过与估计的股四头肌肌肉归一化后则消失（p=0.18 和 0.73）。年龄对女性腿部血液动力学对运动的反应没有影响（单独或归一化为股四头肌），但绝经状态是 FVC 和归一化 FVC 的重要预测因素（p=0.04 和 0.02）。男性运动 FVC 的多元模型（按最强到最弱的预测因素排列）包括股四头肌力量、BMI、静息 FVC、年龄和高密度脂蛋白胆固醇。女性运动 FVC 的多元模型包括股四头肌质量、收缩压、维生素 D、年龄、VO（2max）、腰围和体力活动评分。这些发现表明，除了实际年龄外，还有其他因素调节中年到老年成年人的运动腿部血液动力学，而且这些因素是性别特异性的。
