蔓越莓汁对2型糖尿病男性患者血清葡萄糖、载脂蛋白B、载脂蛋白A-I、脂蛋白(a)和对氧磷酶-1活性的影响。
The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients.
作者信息
Shidfar Farzad, Heydari Iraj, Hajimiresmaiel Seyed Javed, Hosseini Sharieh, Shidfar Shahrzad, Amiri Fariba
机构信息
Department of nutrition, School of Health, Tehran University of Medical Sciences, Iran.
出版信息
J Res Med Sci. 2012 Apr;17(4):355-60.
BACKGROUND
Type 2 diabetic patients are faced with a higher risk of dyslipidemia and cardiovascular disorders. This study was undertaken to assess the effect of consumption of 1 cup cranberry juice by type 2 diabetic patients on serum paraoxonase-1 (PON-1) activity, apoA-1, apoB, glucose, and Lp(a).
METHODS
In a double-blind randomized clinical trial, 58 type 2 diabetic male patients were randomly divided to receive 1 cup cranberry juice (CJ) or placebo drink daily for 12 weeks. Fasting blood were obtained at beginning and at the end of study (12(th) week). Serum glucose and PON-1 activity were measured by enzymatic and colorimetric methods, respectively. ApoB, apoA-I, and Lp(a) were determined immunoturbidimetrically. The data were analyzed by SPSS version 16.
RESULTS
There were significant decrease in serum glucose and apoB (P>0.05 and P>0.01, respectively) and significant increase in serum apoA-1 and PON-1 activity (P>0.05 and P<0.01, respectively) at the end of study in CJ group compared with control group. In CJ group at the end of study, there were significant decrease in serum glucose and apoB (P<0.01 and P<0.01, respectively) and significant increase in serum apo A-1 and PON-1 activity (P<0.01 and P<0.01, respectively) compared with initial values. In CJ group, there was no significant change in Lp(a) at the end of study compared with initial values and also compared with control group.
CONCLUSION
1 cup CJ for 12 weeks is effective in reducing serum glucose and apoB and increasing apoA-1 and PON-1 activity, so may have favorite effects on reducing CVD risk factors in type 2 diabetic male patients.
背景
2型糖尿病患者面临血脂异常和心血管疾病的更高风险。本研究旨在评估2型糖尿病患者饮用1杯蔓越莓汁对血清对氧磷酶-1（PON-1）活性、载脂蛋白A-1、载脂蛋白B、血糖和脂蛋白（a）的影响。
方法
在一项双盲随机临床试验中，58名2型糖尿病男性患者被随机分为两组，每天分别饮用1杯蔓越莓汁（CJ）或安慰剂饮料，持续12周。在研究开始时和结束时（第12周）采集空腹血样。血清葡萄糖和PON-1活性分别采用酶法和比色法测定。载脂蛋白B、载脂蛋白A-I和脂蛋白（a）采用免疫比浊法测定。数据采用SPSS 16版进行分析。
结果
与对照组相比，CJ组在研究结束时血清葡萄糖和载脂蛋白B显著降低（分别为P>0.05和P>0.01），血清载脂蛋白A-1和PON-1活性显著升高（分别为P>0.05和P<0.01）。在CJ组研究结束时，与初始值相比，血清葡萄糖和载脂蛋白B显著降低（分别为P<0.01和P<0.01），血清载脂蛋白A-1和PON-1活性显著升高（分别为P<0.01和P<0.01）。在CJ组，研究结束时脂蛋白（a）与初始值相比以及与对照组相比均无显著变化。
结论
连续12周每天饮用1杯CJ可有效降低血清葡萄糖和载脂蛋白B，提高载脂蛋白A-1和PON-1活性，因此可能对降低2型糖尿病男性患者的心血管疾病风险因素有有益作用。
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