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A new type of antiserum to thyrotropin-releasing hormone; detection of new TRH-immunoreactive cell groups in rat hypothalamus.

作者信息

Anraku T, Iwashita Y, Shirouzu M

机构信息

Department of Neuropsychiatry, Kurume University School of Medicine, Japan.

出版信息

Experientia. 1990 Jul 15;46(7):723-6. doi: 10.1007/BF01939946.

DOI:10.1007/BF01939946
PMID:2115458
Abstract

We produced a new type of antiserum to thyrotropin-releasing hormone (TRH) in rabbits. The immunogen is TRH-BSA, the production of which is based on the formation of an amide bond using carbodiimide (EDC). The specificity of the antiserum was assessed by enzyme immunoassay (EIA) and immunohistochemistry. When using the anti-TRH serum for immunohistochemistry in rat hypothalamus, new magnocellular groups were detected in the ventrolateral parts of the posterior hypothalamus and the dorsal parts of the third ventricle. Colchicine treatment was found not to be necessary to visualize perikarya containing TRH.

摘要

相似文献

1
A new type of antiserum to thyrotropin-releasing hormone; detection of new TRH-immunoreactive cell groups in rat hypothalamus.
Experientia. 1990 Jul 15;46(7):723-6. doi: 10.1007/BF01939946.
2
Production and characterization of antisera to synthetic thyrotropin-releasing hormone (TRH).合成促甲状腺激素释放激素（TRH）抗血清的制备及特性研究
J Histochem Cytochem. 1982 Sep;30(9):926-31. doi: 10.1177/30.9.6813375.
3
New hapten-protein conjugation method using N-(m-aminobenzoyloxy) succinimide as a two-level heterobifunctional agent: thyrotropin-releasing hormone as a model peptide without free amino or carboxyl groups.
J Immunol Methods. 1994 Sep 30;175(1):123-9. doi: 10.1016/0022-1759(94)90338-7.
4
Production of new type of antisera to thyrotropin releasing hormone (TRH) using carbodiimide coupling and an application to immunohistochemistry.使用碳二亚胺偶联法制备新型促甲状腺激素释放激素（TRH）抗血清及其在免疫组织化学中的应用。
Kurume Med J. 1983;30 Suppl:S1-9. doi: 10.2739/kurumemedj.30.supplement_s1.
5
Gonadal steroids regulate rat anterior pituitary levels of TSH-releasing hormone- and pyroglutamyl-glutamyl-proline amide-like immunoreactivity.性腺类固醇调节大鼠垂体前叶促甲状腺激素释放激素和焦谷氨酰 - 谷氨酰 - 脯氨酸酰胺样免疫反应性的水平。
Endocrinology. 1995 Feb;136(2):734-40. doi: 10.1210/endo.136.2.7835305.
6
Thyrotropin releasing hormone (TRH)-immunoreactive cell groups in the rat central nervous system.
Exp Brain Res. 1987;68(1):213-7. doi: 10.1007/BF00255248.
7
Effects of growth hormone-releasing hormone and corticotropin-releasing hormone on the release of thyrotropin-releasing hormone from the rat hypothalamus in vitro.生长激素释放激素和促肾上腺皮质激素释放激素对大鼠下丘脑体外释放促甲状腺激素释放激素的影响。
Exp Clin Endocrinol. 1987 Dec;90(3):365-8. doi: 10.1055/s-0029-1210713.
8
Evidence for thyrotropin-releasing hormone and glucocorticoid receptor-immunoreactive neurons in various preoptic and hypothalamic nuclei of the male rat.雄性大鼠不同视前区和下丘脑核团中促甲状腺激素释放激素和糖皮质激素受体免疫反应性神经元的证据。
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9
Studies on the nature of mammalian hypothalamic thyrotrophin releasing hormone using immunochemical, chromatographic and enzymic techniques.利用免疫化学、色谱分析和酶学技术对哺乳动物下丘脑促甲状腺激素释放激素的性质进行的研究。
J Endocrinol. 1975 Apr;65(1):83-90. doi: 10.1677/joe.0.0650083.
10
Thyrotropin-releasing hormone is not required for thyrotropin secretion in the perinatal rat.围产期大鼠促甲状腺激素分泌不需要促甲状腺激素释放激素。
J Clin Invest. 1979 Apr;63(4):588-94. doi: 10.1172/JCI109340.

本文引用的文献

1
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat.通过胆碱乙酰转移酶免疫组织化学对猫的中枢胆碱能系统进行研究。
J Comp Neurol. 1981 Aug 1;200(2):151-201. doi: 10.1002/cne.902000202.
2
Production and characterization of antisera to synthetic thyrotropin-releasing hormone (TRH).合成促甲状腺激素释放激素（TRH）抗血清的制备及特性研究
J Histochem Cytochem. 1982 Sep;30(9):926-31. doi: 10.1177/30.9.6813375.
3
Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary.
促甲状腺激素释放激素在大鼠下丘脑和垂体中的免疫组织化学定位
Endocrinology. 1982 Jul;111(1):55-65. doi: 10.1210/endo-111-1-55.
4
Ultrastructural localization of TRH-like immunoreactivity.促甲状腺激素释放激素样免疫反应性的超微结构定位
Exp Brain Res. 1980;38(1):1-10. doi: 10.1007/BF00237924.
5
Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance P- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord.
Neuroscience. 1981;6(10):1857-81. doi: 10.1016/0306-4522(81)90028-2.
6
Peptidergic neurones.肽能神经元。
Nature. 1980 Apr 10;284(5756):515-21. doi: 10.1038/284515a0.
7
Thyrotropin releasing hormone, somatostatin, and enkephalin: distribution studies using immunohistochemical techniques.促甲状腺激素释放激素、生长抑素和脑啡肽：运用免疫组织化学技术的分布研究
J Histochem Cytochem. 1980 Apr;28(4):364-6. doi: 10.1177/28.4.6103014.
8
Isolation of thyrotropin releasing factor (TRF) from porcine hypothalamus.从猪下丘脑分离促甲状腺素释放因子（TRF）。
Biochem Biophys Res Commun. 1966 Oct 20;25(2):165-9. doi: 10.1016/0006-291x(66)90574-2.
9
Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat.秋水仙碱对大鼠交感神经中胺储存颗粒转运的影响。
Eur J Pharmacol. 1968 Dec;5(1):111-3. doi: 10.1016/0014-2999(68)90165-9.
10
The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide.促甲状腺激素释放激素与焦谷氨酰-组氨酰-脯氨酸酰胺的化学及激素特性一致性。
Biochem Biophys Res Commun. 1969 Nov 6;37(4):705-10. doi: 10.1016/0006-291x(69)90868-7.