Danilevskaia O N, Lapta G E
Genetika. 1990 Apr;26(4):670-8.
Drosophila melanogaster heat-resistant stock T32 is characterized by additional chromatin in the telomeres of the X and 2L chromosomes. Moreover, elevated (32 degrees C) temperature provokes high instability in the telomere morphology, so that sublines can be obtained which have additional chromatin in different chromosomes. Morphological patterns of telomeres in each subline are stable, if flies are kept at 23 degrees C. It was demonstrated using this model that additional chromatin in the "long" telomeres hybridizes actively with 3H-labelled telomere-associated Dm665 probe. The "short" telomeres show far weaker hybridization, if any, with Dm665. This means that morphological changes in the telomeres of polytene chromosomes result from different degree amplification of the telomere-associated sequences.
黑腹果蝇耐热品系T32的特征是在X染色体和2L染色体的端粒中有额外的染色质。此外，高温（32摄氏度）会引发端粒形态的高度不稳定性，从而可以获得在不同染色体上有额外染色质的亚系。如果将果蝇饲养在23摄氏度，每个亚系中端粒的形态模式是稳定的。利用这个模型证明，“长”端粒中的额外染色质与3H标记的端粒相关Dm665探针能积极杂交。“短”端粒与Dm665的杂交（如果有的话）则弱得多。这意味着多线染色体端粒的形态变化是由端粒相关序列的不同程度扩增引起的。
