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Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.Toll样受体基因多态性与肺曲霉病易感性
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2
Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus.系统性红斑狼疮中Toll样受体5（TLR5）和Toll样受体9（TLR9）基因多态性的关联研究
J Rheumatol. 2007 Aug;34(8):1708-11. Epub 2007 May 15.
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Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.Toll样受体9的基因变异使日本人群易患系统性红斑狼疮。
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Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.Toll样受体9基因多态性影响HIV-1感染的临床进程。
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Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells.肠道上皮细胞中独特的顶端Toll样受体9信号传导维持结肠内稳态。
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Innate immune recognition of viral infection.病毒感染的天然免疫识别
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Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis.Toll样受体9的基因多态性影响对CpG的免疫反应，并导致原发性胆汁性肝硬化中的高IgM血症。
J Autoimmun. 2005 Jun;24(4):347-52. doi: 10.1016/j.jaut.2005.03.002.
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Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.Toll样受体9诱导的I型干扰素保护小鼠免受实验性结肠炎的侵害。
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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.肠道稳态需要Toll样受体识别共生微生物群。
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Toll 样受体 9 基因在日本溃疡性结肠炎患者中的突变和多态性。

Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients.

机构信息

Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.

出版信息

World J Gastroenterol. 2010 Dec 14;16(46):5815-21. doi: 10.3748/wjg.v16.i46.5815.

DOI:10.3748/wjg.v16.i46.5815
PMID:21155002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3001972/
Abstract

AIM

To investigated gene mutations and polymorphisms of TLR9 in Japanese ulcerative colitis (UC) patients.

METHODS

Three single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls, and were assessed in 48 UC patients and 47 healthy controls. Control subjects were matched for age, sex and date of blood sampling from among a subgroup of participants.

RESULTS

TLR9 -1486CC, 1174GG and 2848AA increase the risk of UC [odds ratio (OR) 2.64, 95% confidence interval (95% CI): 1.73-6.53, P = 0.042], and TLR9 -1486TT, 1174AA and 2848GG decrease the risk of UC (OR 0.30, 95% CI: 0.10-0.94, P = 0.039), although there were no correlations between SNPs and disease phenotype or TLR9 mRNA expression.

CONCLUSION

TLR9 polymorphisms are associated with increased susceptibility to UC.

摘要

目的

研究 TLR9 基因在日本溃疡性结肠炎（UC）患者中的突变和多态性。

方法

在健康对照组中鉴定了 TLR9 中的三个单核苷酸多态性（SNP），并在 48 例 UC 患者和 47 例健康对照组中进行了评估。对照组是从参与者的亚组中按年龄、性别和采血日期匹配的。

结果

TLR9-1486CC、1174GG 和 2848AA 增加 UC 的风险[比值比（OR）2.64，95%置信区间（95%CI）：1.73-6.53，P=0.042]，而 TLR9-1486TT、1174AA 和 2848GG 降低 UC 的风险（OR 0.30，95%CI：0.10-0.94，P=0.039），尽管 SNP 与疾病表型或 TLR9 mRNA 表达之间没有相关性。

结论

TLR9 多态性与 UC 的易感性增加有关。