人乳头瘤病毒 DNA 与 P16INK4A 在食管胃交界部同时性癌中的表达。
Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers.
机构信息
Henan Key Laboratory for Esophageal Cancer Research, Department of Gastroenterology, The First Affiliated Hospital, College of Basic Medicine, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
出版信息
World J Gastroenterol. 2010 Dec 14;16(46):5901-6. doi: 10.3748/wjg.v16.i46.5901.
Abstract
AIM
To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16(INK4A) protein expression.
METHODS
Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16). The expression of P16(INK4A) protein was detected using immunohistochemistry.
RESULTS
Among the CC specimens, HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA), respectively (47% vs 29%), and two of both ESCC and GCA. P16(INK4A) was highly expressed in both ESCC and GCA. In the HPV-associated positive CC, higher P16(INK4A) expression was observed in the GCA than in the ESCC (75% vs 25%, P < 0.05).
CONCLUSION
HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA. P16(INK4A) may be a screening index in the HPV-associated carcinoma of gastric cardia.
摘要
目的
探讨同一患者食管和贲门癌（CC）中人类乳头瘤病毒（HPV）感染的关系，并研究 P16（INK4A）蛋白表达的意义。
方法
采用聚合酶链反应检测 HPV 型 16（HPV16）的存在。采用免疫组织化学法检测 P16（INK4A）蛋白的表达。
结果
在 CC 标本中，食管鳞状细胞癌（ESCC）和贲门腺癌（GCA）中分别发现了 8 例和 5 例 HPV16-DNA（47%比 29%），并且在 ESCC 和 GCA 中各有 2 例。P16（INK4A）在 ESCC 和 GCA 中均高度表达。在 HPV 相关阳性 CC 中，GCA 中 P16（INK4A）的表达高于 ESCC（75%比 25%，P<0.05）。
结论
HPV16 作为相关危险因素，可能在 ESCC 和 GCA 的发生发展中起重要作用。P16（INK4A）可能是 HPV 相关贲门癌的筛查指标。
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本文引用的文献
1
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Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1137-9. doi: 10.1158/1055-9965.EPI-10-0089. Epub 2010 Mar 23.
2
3
[Detection of human papillomavirus in tissues of esophageal carcinomas by polymerase chain reaction].[应用聚合酶链反应检测食管癌组织中的人乳头瘤病毒]
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):251-3.
4
[Detection of human papilloma virus type 16 in squamous cell carcinoma of colon and its lymph node metastases].[人乳头瘤病毒16型在结肠癌及其淋巴结转移灶中的检测]
Magy Seb. 2008 Aug;61(4):225-9. doi: 10.1556/MaSeb.61.2008.4.3.
5
p53 Codon 72 polymorphism and the risk of esophageal squamous cell carcinoma.p53基因第72位密码子多态性与食管鳞状细胞癌风险
Mol Carcinog. 2008 Feb;47(2):100-4. doi: 10.1002/mc.20368.
6
Human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in China.中国食管鳞状细胞癌高、低风险区域的人乳头瘤病毒
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7
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8
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Am J Surg Pathol. 2004 Feb;28(2):160-7. doi: 10.1097/00000478-200402000-00002.
9
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Zhonghua Yi Xue Za Zhi. 2003 Nov 10;83(21):1910-4.
10
Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium.中国食管鳞状细胞癌及其癌旁正常上皮中人乳头瘤病毒的检测
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