发光 2-(2′-噻吩基)吡啶环金属化铂(II)配合物及其杯芳烃衍生物的高效单线态氧生成。
Efficient singlet oxygen generation by luminescent 2-(2′-thienyl)pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives.
机构信息
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong SAR, China.
出版信息
Photochem Photobiol. 2010 Nov-Dec;86(6):1414-20. doi: 10.1111/j.1751-1097.2010.00809.x.
Abstract
Luminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh3)X]n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl− (1), n = 0; X = CH3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y]n+ (Y = Cl− (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria.
摘要
发光的金属铂(II)配合物，即[Pt(Thpy)(PPh3)X]n+（HThpy = 2-(2′-噻吩基)吡啶；X = Cl− (1)，n = 0；X = CH3CN (2)，吡啶 (3)，n = 1) 和 [Pt(Thpy)(HThpy)Y]n+（Y = Cl− (4)，n = 0；Y = 吡啶 (5)，n = 1），在真空的乙腈中具有最大发射峰位于 ∼556 和 598nm 的结构发射，发射量子产率和寿命分别高达 0.38 和 26 μs。这些配合物是单线态氧的高效光敏剂，产率高达>90%。配合物 5 对癌细胞表现出光细胞毒性，并且用 5 孵育的细胞的荧光显微镜图像显示在细胞核和线粒体中有大量摄取。
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