[纳洛酮对发热大鼠下丘脑环磷酸腺苷含量及腹侧隔区精氨酸加压素含量的影响]
[Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats].
作者信息
Zhao Hong-yan, Qin Xin, Cao Yu, Yang Yu, Zhao Shu-fen
机构信息
Department of Physiology, China Medical University, Shenyang 110001, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 Aug;25(3):408-10.
AIM
To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats.
METHODS
The fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected.
RESULTS
Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01).
CONCLUSION
Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.
目的
研究纳洛酮对白细胞介素-1β诱导发热大鼠发热反应的影响及机制。
方法
通过向大鼠脑室内注射白细胞介素-1β建立发热模型。观察纳洛酮对发热大鼠体温的影响。检测下丘脑环磷酸腺苷（cAMP）含量及延髓腹外侧区（VSA）血管加压素（AVP）含量。
结果
纳洛酮减轻了白细胞介素-1β诱导的发热，下丘脑cAMP含量及VSA中AVP含量相应降低（P<0.01）。
结论
纳洛酮可抑制大鼠白细胞介素-1β诱导的发热，其机制可能是抑制下丘脑cAMP合成及促进VSA中AVP释放。
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