[黄芩苷对发热大鼠下丘脑前列腺素E2和环磷酸腺苷含量的影响]
[Effects of baicalin on contents of PGE2 and cAMP in hypothalamus of fever rats].
作者信息
Zhao Hong-Yan, Zhang Fan, Fan Shu-Duo
机构信息
Department of Physiology, China Medical University, ShenYang 110001, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002 May;18(2):139-41.
AIM AND METHODS
Both PGE2 and cAMP are important neural mediator of fever. In order to discuss if PGE2 and cAMP are involved in the antipyretic mechanism of baicalin, fever models of rats were made by i.v. injection of endotoxin (ET). The antipyretic action and effects of baicalin on contents of PGE2 and cAMP in hypothalamus were observed.
RESULTS
Baicalin possessed obvious antipyretic effect on fever rats and reversed the effect of ET on contents of PGE2 and cAMP in hypothalamus. Correlation analysis showed that contents of PGE2 and cAMP in hypothalamus were positively correlated with the change of body temperature of rats.
CONCLUSION
Baicalin may exert its antipyretic effect on fever rats by inhibiting increase of contents of PGE2 and cAMP in hypothalamus.
目的与方法
前列腺素E2（PGE2）和环磷酸腺苷（cAMP）均为发热的重要神经介质。为探讨PGE2和cAMP是否参与黄芩苷的解热机制，通过静脉注射内毒素（ET）制备大鼠发热模型，观察黄芩苷的解热作用及其对下丘脑PGE2和cAMP含量的影响。
结果
黄芩苷对发热大鼠具有明显的解热作用，并能逆转ET对下丘脑PGE2和cAMP含量的影响。相关性分析表明，下丘脑PGE2和cAMP含量与大鼠体温变化呈正相关。
结论
黄芩苷可能通过抑制下丘脑PGE2和cAMP含量的升高而发挥对发热大鼠的解热作用。
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