Rebecca L. Cooper Research Laboratories, Mental health Research Institute, Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia.
Int J Neuropsychopharmacol. 2011 Aug;14(7):997-1012. doi: 10.1017/S1461145710001410. Epub 2010 Dec 15.
Many lines of evidence now support the hypothesis that inflammation-related pathways are involved in the pathophysiology of psychiatric disorders. Much of the data underpinning this hypothesis has come from the study of inflammation-related proteins in blood of individuals with mood disorders and schizophrenia. Significantly, recent data have emerged to suggest that changes in inflammation-related pathways are present in the CNS of subjects with psychiatric disorders. It is therefore timely to overview how such data, plus data on the role of inflammation-related proteins in CNS function, is contributing to understanding the pathophysiology of mood disorders and schizophrenia. In addition, it has been suggested that antidepressants, mood stabilizers and antipsychotic drugs act on inflammation-related pathways and therefore measuring levels of inflammation-related proteins in blood may be useful in monitoring treatment responsiveness. Despite these important neuropsychopharmacological discoveries, there is no clear understanding as to how inflammatory-related pathways can precipitate the onset of psychiatric symptoms. This review will focus on data suggesting that acute-reactive proteins and cytokines are affected by the pathophysiology of mood disorders and schizophrenia, that levels of blood inflammation-related proteins before and after treatment might be useful in the diagnosis of psychiatric disorders or measuring responsiveness to drug treatment. Finally, it will be postulated how changes in these proteins affect CNS function to cause psychiatric disorders.
现在有许多证据支持这样一种假设，即与炎症相关的途径参与了精神疾病的病理生理学。这一假设的大部分数据来自于对心境障碍和精神分裂症患者血液中与炎症相关的蛋白质的研究。重要的是，最近有数据表明，精神疾病患者的中枢神经系统存在与炎症相关的途径的变化。因此，及时概述这些数据以及炎症相关蛋白在中枢神经系统功能中的作用，有助于理解心境障碍和精神分裂症的病理生理学。此外，有人提出，抗抑郁药、心境稳定剂和抗精神病药物作用于与炎症相关的途径，因此测量血液中与炎症相关的蛋白质水平可能有助于监测治疗反应。尽管有这些重要的神经精神药理学发现，但人们并不清楚炎症相关途径如何引发精神症状的发作。这篇综述将重点介绍一些数据，这些数据表明急性反应蛋白和细胞因子受心境障碍和精神分裂症病理生理学的影响，治疗前后血液中与炎症相关的蛋白质水平可能有助于精神障碍的诊断或衡量对药物治疗的反应。最后，将推测这些蛋白质的变化如何影响中枢神经系统功能导致精神疾病。
