Bhansali S A, Cass S P, Benitez J T, Mathog R H
Department of Otolaryngology, Wayne State University, Detroit, MI.
Otolaryngol Head Neck Surg. 1990 Jun;102(6):701-8. doi: 10.1177/019459989010200613.
Chronic, unilateral perilymph fistulae were created in cats by removal of the round window membrane and placement of a tympanostomy tube into the round window. Rotary chair, fistula, caloric, and vestibulospinal tests were performed before and after fistulization, and periodically for 2 weeks. At 2 weeks, patency of the fistula was documented by fluorescein injection into the spinal fluid and visualization of leakage into the middle ear bulla via the fistula. All the cats had a patent fistula at 2 weeks, but one of the three cats had a greater perilymph leak than the others. The cat with the more active leak had a spontaneous nystagmus toward the side of the fistula on the first postoperative day; this changed to nystagmus toward the opposite side by the third postoperative day. The other cats had a spontaneous nystagmus toward the opposite side from the first postoperative day. Most abnormal test results returned to normal in the first week after fistulization. Histologic study of the temporal bones revealed that the cat with the greater leak had a wider cochlear aqueduct than the other cats.
通过移除圆窗膜并将鼓膜造孔管置入圆窗，在猫身上制造慢性单侧外淋巴瘘。在造瘘前后以及之后的2周内定期进行转椅试验、瘘管试验、冷热试验和前庭脊髓试验。在第2周时，通过向脑脊液中注射荧光素并观察经由瘘管漏入中耳鼓室的情况来记录瘘管的通畅情况。所有猫在2周时瘘管均通畅，但三只猫中有一只的外淋巴漏比其他两只猫更多。漏液更活跃的那只猫在术后第一天出现向瘘管侧的自发性眼球震颤；到术后第三天，变为向对侧的眼球震颤。其他猫从术后第一天起就出现向对侧的自发性眼球震颤。大多数异常测试结果在造瘘后的第一周恢复正常。颞骨的组织学研究表明，漏液更多的那只猫的蜗水管比其他猫更宽。
