细胞生物学中的交汇途径。
Intersecting pathways in cell biology.
机构信息
Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Sci Signal. 2010 Dec 14;3(152):re10. doi: 10.1126/scisignal.3152re10.
Abstract
The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus, defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest. An emerging link between these processes is a family of proteins called intersectins (ITSNs). These multidomain proteins serve as scaffolds in the assembly of endocytic vesicles and also regulate components of various signaling pathways, including kinases, guanosine triphosphatases, and ubiquitin ligases. This review summarizes research on the role of ITSNs in regulating both endocytic and signal transduction pathways, discusses the link between ITSNs and human disease, and highlights future directions in the study of ITSNs.
摘要
内吞作用途径参与细胞信号的激活和抑制。因此，确定将内吞作用和细胞信号联系起来的调节机制是很有意义的。这些过程之间的一个新联系是一类称为衔接蛋白（ITSNs）的蛋白质。这些多功能蛋白作为内吞小泡组装的支架，也调节各种信号通路的成分，包括激酶、鸟苷三磷酸酶和泛素连接酶。这篇综述总结了关于 ITSNs 在调节内吞作用和信号转导途径中的作用的研究，讨论了 ITSNs 与人类疾病之间的联系，并强调了 ITSNs 研究的未来方向。
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