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乳腺癌的细胞学分级及两种分级系统的比较评估

Cytological grading of breast cancers and comparative evaluation of two grading systems.

作者信息

Wani Farooq Ahmed, Bhardwaj Subhash, Kumar Dinesh, Katoch Pervez

机构信息

Senior Resident, SKIMS Medical College, Srinagar, India.

出版信息

J Cytol. 2010 Apr;27(2):55-8. doi: 10.4103/0970-9371.70738.

DOI:10.4103/0970-9371.70738
PMID:21157550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3001176/
Abstract

AIM

To evaluate and compare the cytograding of breast cancers using Robinson's and Mouriquand's grading methods.

MATERIALS AND METHODS

A 5-year retrospective (from Oct 2000 to Sept 2005) and 1-year prospective study (from Oct 2005 to Oct 2006). A total of 110 fine-needle aspiration cytology (FNAC) cases of breast cancers were studied. These were graded according to Robinson's and Mouriquand's grading methods (grade I-III) followed by comparison of the two methods.

RESULTS

Of the 110 cases graded according to Robinson's method, 28 (25.45%) cases were grade I, 46 (41.81%) grade II, and 36 (32.72%) were grade III, whereas using Mouriquand's grading methods, 28 (25.45%), 42 (38.18%), and 40 (36.36%) cases were graded as grade I, II, and III, respectively. A high degree of concordance was observed between the two grading methods (90.9%). A highly significant relationship between the scores obtained by two methods was also observed (P=0.004).

CONCLUSIONS

A comprehensive cytological grading of breast cancers is possible by using two different methods proposed by Robinson and Mouriquand. In spite of a high degree of concordance between the two methods, the Robinson's grading system has been found to be easier and better because of more objective set of criteria and easy reproducibility.

摘要

目的

使用罗宾逊(Robinson)分级法和穆里昆德(Mouriquand)分级法评估和比较乳腺癌的细胞分级。

材料与方法

进行一项为期5年的回顾性研究(从2000年10月至2005年9月)和一项为期1年的前瞻性研究(从2005年10月至2006年10月)。共研究了110例乳腺癌细针穿刺细胞学(FNAC)病例。根据罗宾逊分级法和穆里昆德分级法(I - III级)对这些病例进行分级,然后比较这两种方法。

结果

按照罗宾逊方法分级的110例病例中,28例(25.45%)为I级,46例(41.81%)为II级,36例(32.72%)为III级;而使用穆里昆德分级法时,分别有28例(25.45%)、42例(38.18%)和40例(36.36%)被评为I级、II级和III级。两种分级方法之间观察到高度一致性(90.9%)。还观察到两种方法获得的分数之间存在高度显著的相关性(P = 0.004)。

结论

使用罗宾逊和穆里昆德提出的两种不同方法对乳腺癌进行全面的细胞学分级是可行的。尽管两种方法之间具有高度一致性,但由于罗宾逊分级系统的标准更客观且易于重现,已发现它更简便且更好。

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Cytopathological grading, as a predictor of histopathological grade, in ductal carcinoma (NOS) of breast, on air-dried Diff-Quik smears.
乳腺肿瘤的细胞学分级——人类与犬类视角
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