Liu Ying, Jin Hong, Xu Zhi-qin, Nan Wen-kao, Wang Tao, Cheng Yi-yong
Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Aug;22(3):358-61.
To investigate the effects of pumpkin polysaccharides on blood glucose and lipids levels in diabetic rats.
Diabetic rats induced by alloxan through intraperitoneal injection were randomly divided into three groups, diabetes, xiaoke pill and pumpkin polysaccharides group, according to weight and blood glucose level. And the normal control group was founded at the same time. The normal control group and diabetes group were lavaged with distilled water, other two groups were respectively lavaged with xiaoke pill or pumpkin polysaccharides. Weighed once a week, and analyzed fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, and free fatty acid level in serum after 4 weeks.
In diabetes group, weight and high density lipoprotein level decreased, and fasting blood glucose, total cholesterol, triglyceride, low density lipoprotein, and free fatty acid level in serum increased significantly. But, all of the indexes changed oppositely in xiaoke pill group and pumpkin polysaccharides group, and effects of pumpkin polysaccharides were better.
Pumpkin polysaccharides can increase the weight, decrease the blood glucose and lipids levels in diabetic rats, and have some good effects to diabetes and diabetes complications.
研究南瓜多糖对糖尿病大鼠血糖和血脂水平的影响。
将腹腔注射四氧嘧啶诱导的糖尿病大鼠按体重和血糖水平随机分为三组，即糖尿病组、消渴丸组和南瓜多糖组，同时设立正常对照组。正常对照组和糖尿病组灌胃蒸馏水，其他两组分别灌胃消渴丸或南瓜多糖。每周称重一次，4周后分析血清空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和游离脂肪酸水平。
糖尿病组大鼠体重和高密度脂蛋白水平下降，血清空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白和游离脂肪酸水平显著升高。但消渴丸组和南瓜多糖组所有指标变化相反，且南瓜多糖组效果更佳。
南瓜多糖可增加糖尿病大鼠体重，降低其血糖和血脂水平，对糖尿病及其并发症有一定的改善作用。
