Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States.
J Am Chem Soc. 2011 Jan 19;133(2):172-5. doi: 10.1021/ja1061664. Epub 2010 Dec 15.
Mesoporous silica with cubic symmetry has attracted interest from researchers for some time. Here, we present the room temperature synthesis of mesoporous silica nanoparticles possessing cubic Pm3n symmetry with very high molar ratios (>50%) of 3-aminopropyl triethoxysilane. The synthesis is robust allowing, for example, co-condensation of organic dyes without loss of structure. By means of pore expander molecules, the pore size can be enlarged from 2.7 to 5 nm, while particle size decreases. Adding pore expander and co-condensing fluorescent dyes in the same synthesis reduces average particle size further down to 100 nm. After PEGylation, such fluorescent aminated mesoporous silica nanoparticles are spontaneously taken up by cells as demonstrated by fluorescence microscopy.
具有立方对称性的介孔硅已经引起了研究人员的关注。在这里，我们提出了在室温下合成具有立方 Pm3n 对称性的介孔硅纳米粒子的方法，其 3-氨丙基三乙氧基硅烷的摩尔比非常高（>50%）。该合成方法非常稳健，例如，在不损失结构的情况下，可以进行有机染料的共缩合。通过使用扩孔剂分子，可以将孔径从 2.7nm 增大到 5nm，同时粒径减小。在相同的合成中添加扩孔剂并共缩合荧光染料，可以将平均粒径进一步减小到 100nm。经 PEG 化后，如荧光显微镜所示，这种荧光胺化介孔硅纳米粒子可以被细胞自发摄取。
