Vallet-Regí María, Balas Francisco, Arcos Daniel
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Angew Chem Int Ed Engl. 2007;46(40):7548-58. doi: 10.1002/anie.200604488.
Research on mesoporous materials for biomedical purposes has experienced an outstanding increase during recent years. Since 2001, when MCM-41 was first proposed as drug-delivery system, silica-based materials, such as SBA-15 or MCM-48, and some metal-organic frameworks have been discussed as drug carriers and controlled-release systems. Mesoporous materials are intended for both systemic-delivery systems and implantable local-delivery devices. The latter application provides very promising possibilities in the field of bone-tissue repair because of the excellent behavior of these materials as bioceramics. This Minireview deals with the advances in this field by the control of the textural parameters, surface functionalization, and the synthesis of sophisticated stimuli-response systems.
近年来，用于生物医学目的的介孔材料研究有了显著增长。自2001年首次提出将MCM-41作为药物递送系统以来，基于二氧化硅的材料，如SBA-15或MCM-48，以及一些金属有机框架已被作为药物载体和控释系统进行讨论。介孔材料既适用于全身递送系统，也适用于可植入的局部递送装置。后一种应用在骨组织修复领域提供了非常有前景的可能性，因为这些材料作为生物陶瓷具有优异的性能。本综述通过控制结构参数、表面功能化以及合成复杂的刺激响应系统来阐述该领域的进展。
