Institut für Chemie, Universität Oldenburg, Carl-von-Ossietzky-Strasse 9-11, 26111 Oldenburg (Germany).
Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7918-22. doi: 10.1002/anie.201403203. Epub 2014 Jun 18.
The C-C bond forming catalytic hydroaminoalkylation of terminal alkenes, 1,3-dienes, or styrenes allows a direct and highly atom efficient (100 %) synthesis of amines which can result in the formation of two regioisomers, the linear and the branched product. We present a new titanium catalyst with 2,6-bis(phenylamino)pyridinato ligands for intermolecular hydroaminoalkylation reactions of styrenes and 1-phenyl-1,3-butadienes that delivers the corresponding linear hydroaminoalkylation products with excellent regioselectivities.
末端烯烃、1,3-二烯或苯乙烯的 C-C 键形成催化氢氨基烷基化反应允许直接且高效原子经济性（100%）合成胺，这可能导致两种区域异构体的形成，即直链和支链产物。我们提出了一种新的钛催化剂，带有 2,6-双（苯氨基）吡啶并配体，用于苯乙烯和 1-苯基-1,3-丁二烯的分子间氢氨基烷基化反应，可获得具有优异区域选择性的相应线性氢氨基烷基化产物。
