Sohal R S, Svensson I, Brunk U T
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275.
Mech Ageing Dev. 1990 Apr 30;53(3):209-15. doi: 10.1016/0047-6374(90)90039-i.
The objective of this study was to further examine the relationship between oxygen free radicals and the aging process in animals. The rate of H2O2, a product of superoxide anion radical dismutation, released by liver mitochondria, was measured in the mouse, rat, guinea pig, rabbit, pig and cow as well as in flight muscle mitochondria of Drosophila melanogaster and the housefly, Musca domestica. The rate of H2O2 generation was inversely related to the maximum life span potential (MLSP) of the species. A 42-fold difference in the rate of H2O2 secretion was found among mammals and an up to 300-fold difference was noted between the insects and the mammals. Results of this study indicate that under identical conditions mitochondria from animals with low MLSP release relatively greater amounts of H2O2.
本研究的目的是进一步探讨动物体内氧自由基与衰老过程之间的关系。测定了小鼠、大鼠、豚鼠、兔、猪和牛肝脏线粒体释放的超氧阴离子自由基歧化产物H2O2的速率，以及果蝇和家蝇飞行肌线粒体中H2O2的释放速率。H2O2生成速率与物种的最大寿命潜能（MLSP）呈负相关。在哺乳动物中，H2O2分泌速率存在42倍的差异，而在昆虫和哺乳动物之间，这一差异高达300倍。本研究结果表明，在相同条件下，MLSP较低的动物线粒体释放的H2O2相对较多。
