Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hum Reprod. 2011 Mar;26(3):553-8. doi: 10.1093/humrep/deq358. Epub 2010 Dec 15.
Uterus transplantation (UTx) research aims towards the introduction of UTx as a treatment for uterine factor infertility. The rat model is the principal rodent model used and this study aims to assess the potential for pregnancy and to assess effects on pregnancy outcome.
Female Lewis rats underwent hysterectomy and received syngeneic uterine transplants (with one horn removed) by end-to-side anastomosis between the common iliac vessels of the recipient and the graft. The graft was placed in an orthotopic position with anastomosis to the upper part of the native uterine horn and vagina to allow for pregnancy by mating. Controls had only one uterine horn removed. Mating and pregnancy frequencies, successful deliveries and pup weight trajectory were compared.
Pregnancy was achieved in rats after UTx with the pregnancy rate, number of pups and growth trajectory of pups being similar to controls. However, numbers of resorbed pregnancies and arrested parturitions were more common in the UTx group.
A model for orthotopic UTx was developed and pregnancies with live offspring were for the first time demonstrated in the rat model of UTx. The model will be useful in future studies of fertility after UTx.
子宫移植（UTx）研究旨在将 UTx 引入治疗子宫因素不孕。大鼠模型是主要的啮齿动物模型，本研究旨在评估妊娠的可能性，并评估对妊娠结局的影响。
雌性 Lewis 大鼠接受子宫切除术，并通过受体和移植物髂总血管的端侧吻合接受同种异体子宫移植（切除一个角）。移植物以原位方式放置，与原生子宫角和阴道的上部吻合，以便通过交配妊娠。对照组仅切除一个子宫角。比较交配和妊娠频率、成功分娩和幼仔体重轨迹。
大鼠 UTx 后可妊娠，妊娠率、产仔数和仔鼠生长轨迹与对照组相似。然而，在 UTx 组中，更多的妊娠被吸收和分娩停止。
建立了一种原位 UTx 模型，并首次在 UTx 大鼠模型中证明了妊娠并产下活胎。该模型将有助于未来 UTx 后生育能力的研究。
