Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Stellenbosch University and Vincent Pallotti Hospital, Cape Town, South Africa.
Gynecol Obstet Invest. 2011;71(2):73-6. doi: 10.1159/000319497. Epub 2010 Dec 16.
To determine whether clomiphene citrate (CC) can be implicated as a cause for central retinal vein occlusion (CRVO) and other visual disturbances.
For this systematic review, we performed a search of the following databases: PubMed (1976 to November 2009), Medline Plus 2009, Cochrane Library (1996 to November 2009), Google and Google Scholar (1996 to November 2009). Thirty-five relevant titles (25 full papers and 10 abstracts) were identified and read by authors. No review has been published in the literature. The publications included describe adverse effects with clomid and selective estrogen receptor modulators and in particular visual disturbances. The population consisted of infertility patients under ovulation induction with CC. The main outcome measures were loss of vision due to CRVO and other visual changes.
CC may predispose to CRVO, but further trials are clearly needed in this area.
Physicians should be aware of the potential risk of CC, especially in patients with associated risk factors for CRVO. If visual disturbances occur, therapy should be terminated and the patient referred for specialist ophthalmic care.
确定枸橼酸氯米酚（CC）是否可能导致视网膜中央静脉阻塞（CRVO）和其他视觉障碍。
本系统评价通过检索以下数据库进行：PubMed（1976 年至 2009 年 11 月）、Medline Plus 2009、Cochrane 图书馆（1996 年至 2009 年 11 月）、Google 和 Google Scholar（1996 年至 2009 年 11 月）。作者阅读了 35 篇相关标题（25 篇全文和 10 篇摘要）。文献中尚未发表过综述。这些出版物描述了 CC 和选择性雌激素受体调节剂的不良反应，特别是视觉障碍。该人群为接受 CC 促排卵的不孕患者。主要结局指标为 CRVO 和其他视觉变化导致的视力丧失。
CC 可能导致 CRVO，但该领域显然需要进一步的试验。
医生应注意 CC 的潜在风险，尤其是在有 CRVO 相关危险因素的患者中。如果出现视觉障碍，应终止治疗并将患者转介至眼科专家处进行治疗。
