Solipuram Vinod, Pokharel Kishor, Ihedinmah Temple
Department of Internal Medicine, Saint Agnes Hospital, Baltimore, MD 21229, USA.
Saint George's University, Great River, NY 11739, USA.
Case Rep Endocrinol. 2021 Sep 7;2021:9987830. doi: 10.1155/2021/9987830. eCollection 2021.
Pulmonary embolism (PE) is a medical emergency. Certain medications like oral contraceptives and hormone replacement therapies have been associated with PE. Clomiphene citrate is a selective estrogen receptor modulator, approved for treating infertility in females, but is being used as an off-label therapy in treating male hypogonadism. Very rarely, clomiphene can cause pulmonary embolism. . A 56-year-old gentleman presented with acute onset shortness of breath and chest discomfort. Upon further workup, he was found to have large volume pulmonary embolism. He was prescribed clomiphene citrate (CC) 2 years ago for hypogonadism. He was started on anticoagulation with improvement in his symptoms, and clomiphene was discontinued.
Pulmonary embolism is a rare but potential complication of clomiphene therapy. In male patients with suspected hypogonadism, the risk of serious thromboembolic complications should be discussed before prescribing CC. Patients on CC have to be carefully monitored for serious side effects.
肺栓塞（PE）是一种医疗急症。某些药物，如口服避孕药和激素替代疗法，与肺栓塞有关。枸橼酸氯米芬是一种选择性雌激素受体调节剂，被批准用于治疗女性不孕症，但目前正被用于治疗男性性腺功能减退的非适应证疗法。枸橼酸氯米芬极少会导致肺栓塞。一名56岁男性因急性发作的呼吸急促和胸部不适前来就诊。进一步检查发现他患有大量肺栓塞。他两年前因性腺功能减退开始服用枸橼酸氯米芬（CC）。开始抗凝治疗后症状有所改善，遂停用了枸橼酸氯米芬。
肺栓塞是枸橼酸氯米芬治疗罕见但可能出现的并发症。对于疑似性腺功能减退的男性患者，在开具CC处方前应讨论严重血栓栓塞并发症的风险。服用CC的患者必须密切监测严重副作用。
