Jimenez-Gomez Corina, Winger Gail, Dean Reginald L, Deaver Daniel R, Woods James H
Department of Pharmacology, University of Michigan Medical School, Medical Center Dr Ann Arbor, Michigan 48109-5632, USA.
Behav Pharmacol. 2011 Feb;22(1):87-90. doi: 10.1097/FBP.0b013e3283423d55.
Amphetamines are the second most highly abused illicit drugs worldwide, yet there is no pharmacological treatment for amphetamine abuse and dependence. Preclinical studies and, more recently, human studies, suggest that the opioid receptor antagonist, naltrexone, might be useful in the treatment of amphetamine abuse. Naltrexone, an opioid receptor antagonist, is currently used for the treatment of alcohol dependence. The aim of this study was to explore the ability of naltrexone to modify self-administration of amphetamine or ethanol in rhesus monkeys. Monkeys were trained to respond to intravenous injections of either D-amphetamine (0.003 mg/kg/injection) or ethanol (0.05 g/kg/injection) on a fixed ratio 30 schedule. Naltrexone (0.01-1 mg/kg) was administered intramuscularly 30 min before the start of treatment test sessions. Naltrexone dose-dependently decreased both amphetamine and ethanol self-administration. These findings support the potential use of naltrexone as therapy for amphetamine and polydrug abuse.
苯丙胺是全球第二大被滥用的非法药物，但目前尚无针对苯丙胺滥用和成瘾的药物治疗方法。临床前研究以及最近的人体研究表明，阿片受体拮抗剂纳曲酮可能对治疗苯丙胺滥用有效。纳曲酮作为一种阿片受体拮抗剂，目前用于治疗酒精成瘾。本研究的目的是探讨纳曲酮改变恒河猴对苯丙胺或乙醇自我给药行为的能力。猴子被训练在固定比率为30的时间表上对静脉注射D-苯丙胺（0.003mg/kg/次注射）或乙醇（0.05g/kg/次注射）做出反应。在治疗测试阶段开始前30分钟，肌肉注射纳曲酮（0.01-1mg/kg）。纳曲酮剂量依赖性地减少了苯丙胺和乙醇的自我给药。这些发现支持了纳曲酮作为治疗苯丙胺和多种药物滥用的潜在用途。
