Mei-Due Yang, Chao-Hsiang Chang, Hwei-Chung Wang, Department of Surgery, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China.
World J Gastrointest Oncol. 2010 Aug 15;2(8):326-31. doi: 10.4251/wjgo.v2.i8.326.
To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.
Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.
There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility.
This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.
在台湾中部人群中研究窖蛋白-1（Cav-1）多态性与结直肠癌（CRC）风险的相关性。
362 例结直肠癌患者和相同数量的年龄和性别匹配的健康对照者进行基因分型。只有那些具有所有单核苷酸多态性数据的匹配者（病例/对照=362/362）被选择进行最终分析。
CRC 组和对照组在 Cav-1 G14713A（rs3807987）和 T29107A（rs7804372）多态性的基因型分布（P=1.6×10(-12)和 3.0×10(-4))和等位基因频率（P=2.3×10(-13)和 4.0×10(-5))方面存在显著差异。对于单倍型分析，Cav-1 G14713A/T29107A 处 GG/AT 或 GG/AA 的个体发生 CRC 的风险降低了 0.68 倍（95%CI：0.48-0.98），而任何其他组合的个体发生 CRC 的风险增加。Cav-1 G14713A 和 T29107A 基因型与吸烟状态对个体 CRC 易感性存在联合作用。
这是首个报道窖蛋白-1 参与结直肠癌的研究，它可能是 CRC 早期检测的新的有用的基因组标记物。
