Bau Da-Tian, Chang Chao-Hsiang, Tsai Ru-Yin, Wang Hwei-Chung, Wang Rou-Fen, Tsai Chia-Wen, Yao Chun-Hsu, Chen Yueh-Sheng, Shyue Song-Kun, Huang Chih-Yang
Department of Urology, China Medical University Hospital, Taichung, Taiwan, Republic of China.
Chin J Physiol. 2011 Jun 30;54(3):153-60. doi: 10.4077/cjp.2011.amm009.
Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on pathological grade. In this case-control study, the association of Cav-1 polymorphisms with bladder cancer risk in a central Taiwanese population was investigated. Three hundred and seventy-five patients with bladder cancer and the same number of age- and gender-matched healthy controls were genotyped. There were significant differences between bladder cancer and control groups in the distributions of their genotypes (P = 1.0 x 10(-12) and 0.299) and allelic frequencies (P = 1.4 x 10(-14) and 6.2 x 10(-3)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for haplotype analysis, subjects who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a decreased risk of bladder cancer compared to subjects with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotypes with smoking status on individual bladder cancer susceptibility. This is the first report providing evidence that Cav-1 was involved in bladder cancer in that the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky haplotype for the development of bladder cancer and may be novel useful genomic markers for early detection of bladder cancer.
许多文章报道小窝蛋白-1基因表达下调，这表明它可能是多种肿瘤中的候选抑癌基因。然而，其在膀胱癌中的作用尚不清楚，可能取决于病理分级。在这项病例对照研究中，我们调查了台湾中部人群中Cav-1基因多态性与膀胱癌风险的关联。对375例膀胱癌患者和相同数量年龄及性别匹配的健康对照进行基因分型。在Cav-1 G14713A（rs3807987）和T29107A（rs7804372）多态性中，膀胱癌组和对照组的基因型分布（P = 1.0×10⁻¹²和0.299）及等位基因频率（P = 1.4×10⁻¹⁴和6.2×10⁻³）存在显著差异。至于单倍型分析，在Cav-1 G14713A/T29107A位点具有GG/AT或GG/AA的受试者与具有GG/TT的受试者相比，患膀胱癌的风险降低，而其他任何组合的受试者风险增加。Cav-1 G14713A和T29107A基因型与吸烟状态对个体膀胱癌易感性存在联合作用。这是首次报道提供证据表明Cav-1与膀胱癌有关，即Cav-1 G14713A的A等位基因有风险，Cav-1 T29107A的A等位基因有保护作用，这两个多态性位点的AA/TT可能是膀胱癌发生最具风险的单倍型，可能是早期检测膀胱癌的新型有用基因组标记。
