Huang Chung-Yu, Tsai Chia-Wen, Hsu Chin-Mu, Chang Wen-Shin, Shui Hao-Ai, Bau Da-Tian
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Tumour Biol. 2015 Aug;36(8):6533-40. doi: 10.1007/s13277-015-3347-9. Epub 2015 Mar 26.
Colorectal cancer, one million cases of diagnosis worldwide annually, is one of the most common malignant tumors and 20 % incidence caused by low penetrance susceptibility genes. Cyclin D1 (CCND1) regulating cell cycle transition may determine the susceptible individuals to genomic instability and carcinogenesis. The study aimed at examining the contribution of CCND1 genotypes to colorectal cancer risk in Taiwan. The genotypes of CCND1 A870G (rs9344) and G1722C (rs678653) were determined among 362 colorectal cancer patients and 362 age- and gender-matched cancer-free controls. Significant differences were observed between colorectal cancer and control groups in the distributions of genotypic (P = 9.71 × 10(-4)) and allelic (P = 0.0017) frequencies at CCND1 A870G. Additionally, individuals carried AG or GG genotype had 0.56- or 0.51-fold higher of odds ratios for developing colorectal cancer than the AA genotype (95 % confidence intervals = 0.40-0.78 and 0.32-0.81, respectively). Furthermore, G allele of CCND1 A870G performed a protective effects for nonsmokers and nonalcohol drinkers (P = 0.0012 and 0.0007, respectively) on colorectal cancer risk. These findings support the concept that the cell cycle regulation may play a role in colorectal cancer initiation and development and CCND1 A870G genotyping maybe a feasible technology for colorectal cancer early detection.
结直肠癌是全球每年确诊病例达100万的最常见恶性肿瘤之一，20%的发病率由低外显率易感基因引起。调节细胞周期转换的细胞周期蛋白D1（CCND1）可能决定了个体对基因组不稳定和致癌作用的易感性。本研究旨在探讨CCND1基因分型对台湾地区结直肠癌风险的影响。在362例结直肠癌患者和362例年龄及性别匹配的无癌对照者中，测定了CCND1 A870G（rs9344）和G1722C（rs678653）的基因型。在CCND1 A870G的基因型频率（P = 9.71×10⁻⁴）和等位基因频率（P = 0.0017）分布上，结直肠癌组与对照组之间存在显著差异。此外，携带AG或GG基因型的个体患结直肠癌的比值比分别比AA基因型高0.56倍或0.51倍（95%置信区间分别为0.40 - 0.78和0.32 - 0.81）。此外，CCND1 A870G的G等位基因对非吸烟者和非饮酒者的结直肠癌风险具有保护作用（分别为P = 0.0012和0.0007）。这些发现支持了细胞周期调控可能在结直肠癌的发生和发展中起作用的概念，并且CCND1 A870G基因分型可能是一种用于结直肠癌早期检测的可行技术。
