Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population.

Caveolin-1() was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in have been identified, but their effects on BC were not clear. This case-control study aims to evaluate the relationship between polymorphisms and BC risk. 560 BC patients and 583 healthy controls were enrolled in the present study, all from Chinese Han population. We detected 3 single nucleotide polymorphisms (rs3807987, rs1997623, and rs7804372) in using the Sequenom MassARRAY method. The association between genotypes and BC risk was assessed in six genetic models by calculating the odds ratio (OR) and 95% confidence intervals (95% CIs) with χ-test. The rs3807987 polymorphism was observed to increase the risk of BC And the A allele of rs3807987 relates to a larger tumor size (≥2cm) and lower incidence of PR-positive BC while the AA genotype of rs7804372 associates with a higher ER and Her-2 positive rate among BC patients. In addition, AGT haplotype was linked to a decreased risk of BC (OR =0.64, 95%CI=0.44-0.93), whereas CAT haplotype was related to an increased BC risk (OR =1.74, 95%CI=1.04-2.92). Our study suggests that rs3807987 can increase the BC risk among Chinese Han women. And the rs3807987 and rs7804372 in may serve as predictors for prognosis of BC.