肝细胞癌患者中α-甲胎蛋白特异性CD4和CD8 T细胞反应
Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma.
作者信息
Behboudi Shahriar, Pereira Stephen P
机构信息
Shahriar Behboudi, Stephen P Pereira, UCL Institute of Hepatology, University College London, Royal Free Hospitals, London NW3 2QG, United Kingdom.
出版信息
World J Hepatol. 2010 Jul 27;2(7):256-60. doi: 10.4254/wjh.v2.i7.256.
Abstract
The presence of CD8 T cell responses to tumor associated antigens have been reported in patients with different malignancies. However, there is very little information on a comparable CD8 and CD4 T cell response to a tumor antigen in liver cancer patients. Here, we re-examine the kinetic and the pattern of T helper 1 and cytotoxic T lymphocyte responses to alpha-fetoprotein (AFP), a tumor rejection antigen in hepatocellular carcinoma (HCC). Then, we discuss the possibility of using AFP-based immunotherapy in combination with necrotizing treatments in HCC patients.
摘要
在患有不同恶性肿瘤的患者中，已报道存在针对肿瘤相关抗原的CD8 T细胞反应。然而，关于肝癌患者中针对肿瘤抗原的类似CD8和CD4 T细胞反应的信息非常少。在这里，我们重新审视了对甲胎蛋白（AFP）（一种肝细胞癌（HCC）中的肿瘤排斥抗原）的辅助性T细胞1和细胞毒性T淋巴细胞反应的动力学和模式。然后，我们讨论了在HCC患者中将基于AFP的免疫疗法与坏死性治疗联合使用的可能性。
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