Pertsov S S, Koplik E V, Kalinichenko L S, Simbirtsev A S
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2010 Dec;150(1):9-12. doi: 10.1007/s10517-010-1054-5.
We studied the effects of immunomodulatory cytokine interleukin-1β on lipid peroxidation in emotiogenic structures of the brain (hypothalamus, sensorimotor cortex, and amygdala) of behaviorally active and passive rats with different prognostic resistance to stress. Immobilization of animals with simultaneous electrocutaneous stimulation (1 h) served as the model of acute emotional stress. Intraperitoneal injection of IL-1β (5 μg/kg) was followed by accumulation of malonic dialdehyde (end-product of lipid peroxidation) in all structures of the brain in passive rats, as well as in the hypothalamus of active animals. As differentiated from active rats, stress exposure in passive specimens was accompanied by a selective increase in malonic dialdehyde content in the sensorimotor cortex and amygdala. Pretreatment with IL-1β prevented activation of lipid peroxidation in the studied structures of the brain in passive rats after stress exposure. Our results show the specific effect of IL-1β on free-radical processes in the hypothalamus, sensorimotor cortex, and amygdala in rats with various behavioral parameters. Regional features of lipid peroxidation in emotiogenic structures of the brain in animals with different emotional reactivity probably contribute to the existence of significant variations in the individual resistance to emotional stress.
我们研究了免疫调节细胞因子白细胞介素-1β对具有不同应激预后抵抗力的行为活跃和被动大鼠大脑情绪发生结构（下丘脑、感觉运动皮层和杏仁核）脂质过氧化的影响。将动物固定并同时进行电皮肤刺激（1小时）作为急性情绪应激模型。腹腔注射白细胞介素-1β（5μg/kg）后，被动大鼠大脑的所有结构以及活跃动物的下丘脑均出现丙二醛（脂质过氧化终产物）积累。与活跃大鼠不同，被动大鼠在应激暴露后，感觉运动皮层和杏仁核中的丙二醛含量选择性增加。白细胞介素-1β预处理可防止被动大鼠在应激暴露后所研究的大脑结构中脂质过氧化的激活。我们的结果表明白细胞介素-1β对具有不同行为参数的大鼠下丘脑、感觉运动皮层和杏仁核中的自由基过程具有特定作用。具有不同情绪反应性的动物大脑情绪发生结构中脂质过氧化的区域特征可能导致个体对情绪应激的抵抗力存在显著差异。
