Pertsov S S, Pirogova G V
Department for Physiology of Emotions and Emotional Stress, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2004 Jul;138(1):14-7. doi: 10.1023/b:bebm.0000046926.71206.95.
We studied the effects of acute stress and exogenous melatonin in various doses on the intensity of lipid peroxidation in emotiogenic structures of the brain and liver of rats with different activity in the open field. Stress had no effect on the content of malonic dialdehyde in the hypothalamus, sensorimotor cortex, and liver of active and passive rats receiving physiological saline. The influence of melatonin on malonic dialdehyde content depended on the dose of this substance. The amount of malonic dialdehyde in brain structures (active and passive rats) and liver (active rats) increased after administration of exogenous melatonin in doses of 0.5 and 2 mg/kg, but decreased after treatment with the hormone in a dose of 1 mg/kg. Melatonin in various doses decreased malonic dialdehyde content in the liver of passive rats. The effects of melatonin are partly related to modulation of lipid peroxidation in central and peripheral tissues of the organism.
我们研究了急性应激和不同剂量外源性褪黑素对旷场活动不同的大鼠大脑和肝脏情感发生结构中脂质过氧化强度的影响。应激对接受生理盐水的活跃和被动大鼠的下丘脑、感觉运动皮层及肝脏中丙二醛含量没有影响。褪黑素对丙二醛含量的影响取决于该物质的剂量。给予0.5和2mg/kg剂量的外源性褪黑素后，大脑结构（活跃和被动大鼠）及肝脏（活跃大鼠）中的丙二醛量增加，但给予1mg/kg剂量的该激素后丙二醛量减少。不同剂量的褪黑素可降低被动大鼠肝脏中的丙二醛含量。褪黑素的作用部分与机体中枢和外周组织中脂质过氧化的调节有关。
