拟肾上腺素药和血清素对细胞抑制性骨髓抑制中多能基质和造血前体的影响。

Effect of adrenomimetics and serotonin on polypotent stromal and hemopoietic precursors in cytostatic myelosuppression.

作者信息

Skurikhin E G, Khmelevskaya E S, Pershina O V, Andreeva T V, Ermakova N N, Dygai A M

机构信息

Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.

出版信息

Bull Exp Biol Med. 2010 Dec;150(1):113-6. doi: 10.1007/s10517-010-1083-0.

DOI:10.1007/s10517-010-1083-0

PMID:21161067

Abstract

Effects of serotonin and adrenomimetics (phenylephrine and isoprenaline) on bone marrow stromal and polypotent hemopoietic precursors were studied in vitro on the model of cyclophosphamide-induced myelosuppression. It was found that under conditions of myelosuppression, adrenomimetics potentiate differentiation of polypotent hemopoietic precursors into mature precursors (granulocyte-macrophage and granulocyte CFU) initiated by granulocytic CSF, while serotonin suppresses these processes. Adrenomimetics (especially, isoprenaline) abolish high rate of division of stromal precursors and suppress the growth of granulocytic CSF induced by fibroblast-like cells. Serotonin does not affect proliferation of stromal precursors, but potentiates the granulocytopoiesis-stimulating effects of fibroblasts.

摘要

在环磷酰胺诱导的骨髓抑制模型上，体外研究了血清素和拟肾上腺素药（去氧肾上腺素和异丙肾上腺素）对骨髓基质和多能造血前体的影响。发现在骨髓抑制条件下，拟肾上腺素药可增强由粒细胞集落刺激因子引发的多能造血前体向成熟前体（粒细胞 - 巨噬细胞和粒细胞集落形成单位）的分化，而血清素则抑制这些过程。拟肾上腺素药（尤其是异丙肾上腺素）消除了基质前体的高分裂率，并抑制成纤维样细胞诱导的粒细胞集落刺激因子的生长。血清素不影响基质前体的增殖，但增强成纤维细胞的粒细胞生成刺激作用。