Department of Health, University of Rome Foro Italico, Rome, Italy.
Knee Surg Sports Traumatol Arthrosc. 2011 Jun;19(6):980-7. doi: 10.1007/s00167-010-1350-7. Epub 2010 Dec 15.
To investigate the effects of hyperthermia on knee osteoarthritis (OA) in a randomized placebo-controlled double-blind clinical trial.
Sixty-three patients with clinical evidence and radiographic confirmation of knee OA (Kellgren and Lawrence grades II and III) were randomized to either three 30-min sessions of hyperthermia per week for 4 weeks were administered using a 433.92 MHZ microwave generator or receive placebo treatment (machine not turned on) for same number of sessions. The Western Ontario McMaster Universities (WOMAC) questionnaire and the Timed Up and Go test (TUGT), a performance-based measure of function, were obtained at baseline (week 0), at the end of treatment (week 4), and at final follow-up (week 16).
The treatment group showed a significant decrease in the overall WOMAC score and each of its components, and in the TGUG test between the beginning (week 0) and the end of treatment (week 4), as well as at final follow-up (week 16). In the placebo group, a significant fall was only visible in the pain subscore at week 4. However, the mean improvement was only 1 point and was lost at final follow-up (P=0.332). There was a significant difference in pain -7.4 pre-post (P<0.01), -8.1 pre-follow-up (P<0.01); stiffness -4.6 pre-post (P<0.01), -5.1 pre-follow-up (P<0.01); activities daily living (ADL) -30.9 pre-post (P<0.01), -33.2 pre-follow-up (P<0.01); and WOMAC total score -43 pre-post (P<0.01), -46.4 pre-follow-up (P<0.01); and in TGUG test -2.4 pre-post (P<0.01), -2.9 pre-follow-up (P<0.01) between the treatment and placebo group over the whole length of the trial.
A 433.92 MHz microwave hyperthermia regimen showed beneficial effects in patients with moderate knee OA to reduce pain and to improve their physical function.
I.
在一项随机安慰剂对照双盲临床试验中，研究热疗对膝骨关节炎（OA）的影响。
63 例临床和影像学证实的膝骨关节炎（Kellgren 和 Lawrence 分级 II 和 III）患者被随机分为三组，每周接受 3 次 30 分钟的热疗，共 4 周，使用 433.92MHz 微波发生器进行治疗；或接受相同次数的安慰剂治疗（机器未开启）。在基线（第 0 周）、治疗结束时（第 4 周）和最终随访时（第 16 周），采用 Western Ontario McMaster Universities（WOMAC）问卷和计时起立行走测试（TUGT），这是一种基于表现的功能测量方法，对患者进行评估。
治疗组在整个 WOMAC 评分及其各组成部分以及 TUGT 测试中，从开始（第 0 周）到治疗结束（第 4 周）以及最终随访（第 16 周），均显示出显著下降。在安慰剂组中，仅在第 4 周时疼痛子评分显著下降。然而，平均改善仅为 1 分，且在最终随访时丢失（P=0.332）。疼痛方面，治疗组患者在治疗前后的评分差值为 -7.4（P<0.01），在治疗前后的评分差值为 -8.1（P<0.01）；僵硬方面，治疗组患者在治疗前后的评分差值为 -4.6（P<0.01），在治疗前后的评分差值为 -5.1（P<0.01）；日常活动能力（ADL）方面，治疗组患者在治疗前后的评分差值为 -30.9（P<0.01），在治疗前后的评分差值为 -33.2（P<0.01）；WOMAC 总评分方面，治疗组患者在治疗前后的评分差值为 -43（P<0.01），在治疗前后的评分差值为 -46.4（P<0.01）；TUGT 测试方面，治疗组患者在治疗前后的评分差值为 -2.4（P<0.01），在治疗前后的评分差值为 -2.9（P<0.01）。这些差异在整个试验过程中均显著优于安慰剂组。
433.92MHz 微波热疗方案对中度膝骨关节炎患者具有有益的疗效，可以减轻疼痛并改善其身体功能。
I。
