Department of Diagnostic Imaging, The Hospital for Sick Children, Neurosciences & Mental Health, Research Institute, 555 University Ave., Toronto, M5G 1X8, Canada.
Pediatr Radiol. 2011 Jun;41(6):702-10. doi: 10.1007/s00247-010-1955-5. Epub 2010 Dec 16.
T1- and T2-W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable.
To determine whether high-resolution T1- and T2-W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value.
Thirty preterm neonates born between 24 and 32 weeks' gestational age were scanned during the first 2 weeks after birth. T1- and T2-W high-resolution sequences were optimized in terms of signal-to-noise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences.
No differences were found between conventional and high-resolution T1-W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T2-W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T2-W images.
High-resolution T1- and T2-W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.
用于获取新生儿脑的诊断信息和形态测量的 T1- 和 T2-W MR 序列通常使用不同的成像协议进行采集。优化一种协议以获取这两种信息是有价值的。
确定优化用于早产儿脑成像的高分辨率 T1- 和 T2-W 容积序列是否可以提供诊断和形态学价值。
30 名胎龄在 24 至 32 周之间的早产儿在出生后 2 周内进行了扫描。T1- 和 T2-W 高分辨率序列在信噪比、对比噪声比和扫描时间方面进行了优化，并与传统的基于自旋回波的序列进行了比较。
在诊断信心、图像质量和运动伪影方面，常规和高分辨率 T1-W 序列之间没有差异。对于图像质量，传统序列优于高分辨率 T2-W 序列。高分辨率 T1 图像更好地描绘了丘脑髓鞘和颞上沟。使用常规和高分辨率 T2-W 图像检测髓鞘化和脑回差异无统计学意义。
高分辨率 T1- 和 T2-W 容积序列可用于极早产儿的临床 MRI 中，以提供诊断和形态学信息。
