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[普萘洛尔成功治疗眼眶毛细血管瘤]

[Successful treatment of orbital capillary hemangioma with propranolol].

作者信息

Mai C, Vega-Pérez A, Koch M, Bertelmann E

机构信息

Klinik und Poliklinik für Augenheilkunde, Charité Universitätsmedizin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

出版信息

Ophthalmologe. 2011 Apr;108(4):364-7. doi: 10.1007/s00347-010-2281-x.

DOI:10.1007/s00347-010-2281-x
PMID:21161237
Abstract

We describe the case of a 3-month-old infant suffering from rapidly progressive orbital capillary hemangioma which we treated with systemic propranolol over a period of 3.5 months. A few weeks after the onset of treatment, the exophthalmus had regressed and after 3 months of treatment the tumor completely vanished. This result is consistent with recent publications and supports the role of propranolol in the treatment of problematic hemangioma.

摘要

我们描述了一名3个月大的婴儿患有快速进展性眼眶毛细血管瘤的病例,我们用系统性普萘洛尔对其进行了3.5个月的治疗。治疗开始几周后,眼球突出有所消退,治疗3个月后肿瘤完全消失。这一结果与近期的出版物一致,并支持了普萘洛尔在治疗有问题的血管瘤中的作用。

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1
[Successful treatment of orbital capillary hemangioma with propranolol].[普萘洛尔成功治疗眼眶毛细血管瘤]
Ophthalmologe. 2011 Apr;108(4):364-7. doi: 10.1007/s00347-010-2281-x.
2
Propranolol for orbital hemangioma.普萘洛尔用于眼眶血管瘤
Ophthalmology. 2010 Jan;117(1):195-195.e4. doi: 10.1016/j.ophtha.2009.08.040.
3
[Orbital tumor in infancy. Capillary hemangioma of the orbits].[婴儿眼眶肿瘤。眼眶毛细血管瘤]
Ophthalmologe. 1998 Jun;95(6):442-3. doi: 10.1007/s003470050295.
4
Propranolol for the treatment of orbital infantile hemangiomas.普萘洛尔治疗眼眶婴幼儿血管瘤。
Ophthalmic Plast Reconstr Surg. 2011 May-Jun;27(3):190-4. doi: 10.1097/IOP.0b013e318201d344.
5
Efficacy of systemic propranolol for severe infantile haemangioma of the orbit and eyelid: a case study of eight patients.系统普萘洛尔治疗眶和眼睑严重婴幼儿血管瘤的疗效:8 例病例研究。
Br J Ophthalmol. 2012 Mar;96(3):370-4. doi: 10.1136/bjophthalmol-2011-300047. Epub 2011 Jun 14.
6
Refractive and structural changes in infantile periocular capillary haemangioma treated with propranolol.普萘洛尔治疗婴幼儿眶周毛细血管血管瘤的屈光和结构变化。
Eye (Lond). 2011 Dec;25(12):1627-34. doi: 10.1038/eye.2011.233. Epub 2011 Sep 16.
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Propranolol treatment for periocular capillary hemangiomas.普萘洛尔治疗眼周毛细血管瘤
J AAPOS. 2010 Jun;14(3):199-200. doi: 10.1016/j.jaapos.2010.05.003.
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Epithelioid hemangioma responsive to oral propranolol.上皮样血管内皮细胞瘤对口服普萘洛尔有反应。
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[A case of propranolol therapy for infantile capillary hemangiomas of the parotis].[普萘洛尔治疗腮腺婴幼儿毛细血管瘤1例]
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引用本文的文献

1
Oral propranolol for treatment of pediatric capillary hemangiomas.口服普萘洛尔治疗小儿毛细血管瘤。
J Ophthalmic Vis Res. 2012 Apr;7(2):130-3.

本文引用的文献

1
Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action.普萘洛尔治疗婴幼儿血管瘤:作用机制的分子学见解。
Br J Dermatol. 2010 Aug;163(2):269-74. doi: 10.1111/j.1365-2133.2010.09848.x. Epub 2010 May 8.
2
[Infantile hemangioma. Successful treatment with propranolol].[婴儿血管瘤。普萘洛尔治疗成功]
Hautarzt. 2010 Apr;61(4):290-2. doi: 10.1007/s00105-010-1938-3.
3
Propranolol therapy for infantile haemangiomas: review of the literature.普萘洛尔治疗婴幼儿血管瘤:文献综述
Int J Pediatr Otorhinolaryngol. 2010 Apr;74(4):338-42. doi: 10.1016/j.ijporl.2010.01.001. Epub 2010 Feb 1.
4
Propranolol for infantile hemangiomas: early experience at a tertiary vascular anomalies center.普萘洛尔治疗婴幼儿血管瘤:三级血管畸形中心的早期经验。
Laryngoscope. 2010 Apr;120(4):676-81. doi: 10.1002/lary.20807.
5
[Propranolol therapy to treat problematic hemangiomas : a new standard therapy makes its debut].[普萘洛尔治疗婴幼儿血管瘤:一种新的标准疗法首次亮相]
Hautarzt. 2009 Dec;60(12):1013-6. doi: 10.1007/s00105-009-1856-4.
6
Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants.婴儿血管瘤:一个与低体重儿出生率上升相关的新出现的健康问题。
J Pediatr. 2008 Nov;153(5):712-5, 715.e1. doi: 10.1016/j.jpeds.2008.05.043.
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Propranolol for severe hemangiomas of infancy.普萘洛尔治疗婴儿重症血管瘤。
N Engl J Med. 2008 Jun 12;358(24):2649-51. doi: 10.1056/NEJMc0708819.
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Hemangiomas in infancy and childhood. S 2k Guideline of the German Society of Dermatology with the working group Pediatric Dermatology together with the German Society for Pediatric Surgery and the German Society for Pediatric Medicine.婴幼儿血管瘤。德国皮肤病学会与儿科皮肤病学工作组、德国小儿外科学会和德国儿科学会联合发布的S2k指南。
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9
Beta blockade induces apoptosis in cultured capillary endothelial cells.β受体阻滞剂可诱导培养的毛细血管内皮细胞凋亡。
In Vitro Cell Dev Biol Anim. 2002 May;38(5):298-304. doi: 10.1290/1071-2690(2002)038<0298:BBIAIC>2.0.CO;2.