Peeters B W, Kerbusch J M, van Luijtelaar E L, Vossen J M, Coenen A M
Department of Comparative and Physiological Psychology, University of Nijmegen, The Netherlands.
Behav Genet. 1990 May;20(3):453-60. doi: 10.1007/BF01065569.
All rats of the WAG inbred strain show electrophysiological and behavioral phenomena reminiscent of human absence epilepsy. To study the genetic architecture of this kind of epilepsy, WAG rats were cross bred with inbred ACI rats which show no signs of epilepsy. Number and duration of spike-wave discharges per hour were determined from 24-h recordings of cortical EEG in parental strains and reciprocal F1 hybrids. All hybrids showed spike-wave discharges, indicating complete dominance for occurrence, but different genetic backgrounds were suggested for number and duration of the phenomena. These results imply that more than one gene is involved in absence epilepsy. Some genes determine the occurrence, while others may manipulate the actual number and duration of the epileptic phenomena.
所有近交系WAG大鼠均表现出类似于人类失神癫痫的电生理和行为现象。为研究这种癫痫的遗传结构，将WAG大鼠与无癫痫迹象的近交系ACI大鼠进行杂交。通过对亲本品系和正反交F1代杂种大鼠进行24小时皮质脑电图记录，确定每小时棘波-慢波放电的次数和持续时间。所有杂种大鼠均表现出棘波-慢波放电，表明在发作方面呈完全显性，但对于该现象的次数和持续时间，提示存在不同的遗传背景。这些结果表明，失神癫痫涉及多个基因。一些基因决定发作，而另一些基因可能控制癫痫现象的实际次数和持续时间。
