Peeters B W, Kerbusch J M, Coenen A M, Vossen J M, van Luijtelaar E L
Department of CNS Pharmacology, Organon International B.V., Oss, The Netherlands.
Behav Genet. 1992 May;22(3):361-8. doi: 10.1007/BF01066667.
The WAG inbred strain might be an animal model for human absence epilepsy. To study the inheritance pattern of absence epilepsy, WAG rats were crossbred, in a classical Mendelian way, with inbred ACI rats which show no signs of epilepsy. In the parental strains, reciprocal F1 hybrids, F2, B1, and B2 generations, the number and duration of spike-wave discharges were determined. One hundred percent of the F1 animals showed spike-wave discharges, while the percentages for the F2, B1, and B2 generations were 79, 95, and 37%, respectively. These results suggest that the occurrence of spike-wave discharges is determined by one gene with a dominant mode of inheritance. Cavalli's least-squares fitting procedure suggested different genetic models for the two parameters (number and duration) during the two periods (dark and light). These results confirm our previous findings (Peeters et al., Behav. Genet. 20, 453-460, 1990) that a number of genes are involved in absence epilepsy. One dominant gene appears to determine the occurrence, however, while others manipulate the number and duration of epileptic phenomena during the two periods dark and light.
WAG近交系可能是人类失神癫痫的一种动物模型。为了研究失神癫痫的遗传模式，WAG大鼠与无癫痫迹象的近交ACI大鼠以经典孟德尔方式进行杂交。在亲本品系、正反交F1杂种、F2、B1和B2代中，测定了棘波放电的数量和持续时间。100%的F1动物出现棘波放电，而F2、B1和B2代的这一比例分别为79%、95%和37%。这些结果表明，棘波放电的发生由一个具有显性遗传模式的基因决定。卡瓦利最小二乘法拟合程序为两个时期（黑暗和光照）的两个参数（数量和持续时间）提出了不同的遗传模型。这些结果证实了我们之前的发现（Peeters等人，行为遗传学，20，453 - 460，1990），即失神癫痫涉及多个基因。然而，一个显性基因似乎决定了其发生，而其他基因则在黑暗和光照这两个时期控制癫痫现象的数量和持续时间。
