Van Luijtelaar E L, Coenen A M
Department of Psychology, University of Nijmegen, The Netherlands.
Epilepsy Res. 1988 Sep-Oct;2(5):331-6. doi: 10.1016/0920-1211(88)90042-3.
In order to study putative time of day effects upon the number and mean duration of spike-wave complexes, 19 rats of the WAG/Rij strain were equipped with cortical EEG electrodes. The EEGs were recorded continuously for 48 h. A cosinor analysis was applied to both the data on each subject and the mean scores of all rats. A definite 24 h rhythm was found for the number of spike-wave complexes occurring each hour. The acrophase appeared during the early hours of the dark period, while the minimum was found to take place immediately after the onset of light. A 24 h rhythm was less prominent for the mean duration of the spike-wave complexes. Finally, there were no differences found between the 2 days of the 48 h registration period, suggesting that the number and duration of the spike-wave complexes found on a given day are representative for the following day.
为了研究一天中不同时段对棘波复合波数量和平均持续时间的潜在影响，给19只WAG/Rij品系的大鼠植入了皮质脑电图电极。脑电图连续记录48小时。对每个受试者的数据以及所有大鼠的平均得分都进行了余弦分析。发现每小时出现的棘波复合波数量存在明确的24小时节律。峰值相位出现在黑暗期的早期，而最小值则出现在光照开始后不久。棘波复合波的平均持续时间的24小时节律不太明显。最后，在48小时记录期的两天之间未发现差异，这表明在某一天发现的棘波复合波的数量和持续时间代表了第二天的情况。
