Alcina A, Fedetz M, Ndagire D, Fernández O, Leyva L, Guerrero M, Arnal C, Delgado C, Matesanz F
Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Granada, Spain.
Tissue Antigens. 2008 Aug;72(2):158-61. doi: 10.1111/j.1399-0039.2008.01075.x.
Several but not all studies have provided evidence for the association between multiple sclerosis (MS) and the T244I variant of the interleukin-7 receptor-alpha gene (IL7RA), rs6897932. We performed a new replication case-control study in 599 MS patients and 594 healthy controls, all Caucasians from the south of Spain. The genotype and allele frequencies differed between MS cases and controls. The IL7RA rs6897932 C allele and the CC genotype were found to be factors for disease susceptibility [per allele odds ratio (OR) 1.32, 95% CI 1.1-1.6, P=0.0031; per CC genotype vs TT + TC genotypes, OR 1.5, 95% CI 1.18-1.87, P=0.0007]. The combined data analysis included 3324 cases and 5032 controls of Europeans and Americans of European origin resulting in stronger association with similar OR (P=1.9 x 10E-9). These findings in our sample support previous reported association studies between IL7RA rs6897932 and MS.
一些但并非所有研究都为多发性硬化症（MS）与白细胞介素7受体α基因（IL7RA）的T244I变体rs6897932之间的关联提供了证据。我们对599例MS患者和594名健康对照者进行了一项新的重复病例对照研究，所有研究对象均为来自西班牙南部的白种人。MS病例组和对照组之间的基因型和等位基因频率存在差异。发现IL7RA rs6897932的C等位基因和CC基因型是疾病易感性因素[每个等位基因比值比（OR）为1.32，95%置信区间为1.1 - 1.6，P = 0.0031；CC基因型与TT + TC基因型相比，OR为1.5，95%置信区间为1.18 - 1.87，P = 0.0007]。综合数据分析纳入了3324例病例和5032名欧洲人和具有欧洲血统的美国人作为对照，结果显示关联更强，OR值相似（P = 1.9×10⁻⁹）。我们样本中的这些发现支持了先前报道的IL7RA rs6897932与MS之间的关联研究。
