Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
J Neuroimmunol. 2020 Apr 15;341:577166. doi: 10.1016/j.jneuroim.2020.577166. Epub 2020 Jan 22.
Multiple sclerosis (MS) is recognized as the most prevalent chronic inflammatory neurological disorder diagnosed in young adults. Recent evidence suggests that the T244I polymorphism of the IL7Rα gene (rs6897932) May influence MS susceptibility; however, individual studies have provided conflicting and controversial results. Therefore, this meta-analysis was conducted to assess the association between the IL7R T244I polymorphism and the risk of MS.
An extensive search for published literature up to May 2019 was accomplished in the electronic databases, and 28 studies consisting of 16,260 MS patients and 18,335 controls were included. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to investigate the strength of association.
The results of the present meta-analysis represented significant association between the IL7R T244I polymorphism and MS susceptibility. (recessive model: OR = 1.126, 95% CI 1.026-1.236, P = .012; dominant model: OR = 1.172, 95% CI 1.024-1.341, P = .021; homozygous model: OR = 1.213, 95% CI 1.038-1.417, P = .015; and allelic model: OR = 1.109, 95% CI 1.025-1.200, P = .010, respectively). In the subgroup analysis according to region, our findings showed significant association in Europe. However, no association was found in Middle East.
The current meta-analysis demonstrated that the C allele of IL7R T244I polymorphism might be a risk factor for the MS susceptibility in Europe but not in Middle East.
多发性硬化症（MS）是一种常见的青年期起病的慢性炎症性神经系统疾病。最近的证据表明，白细胞介素 7 受体α（IL7Rα）基因 T244I 多态性（rs6897932）可能影响 MS 的易感性；然而，单独的研究结果存在矛盾和争议。因此，进行了这项荟萃分析，以评估 IL7R T244I 多态性与 MS 风险之间的关系。
对截至 2019 年 5 月的已发表文献进行了广泛的电子数据库检索，共纳入 28 项研究，包括 16260 例 MS 患者和 18335 例对照。计算合并的比值比（OR）及其 95%置信区间（CI）以评估关联强度。
本荟萃分析的结果表明，IL7R T244I 多态性与 MS 易感性之间存在显著关联。（隐性模型：OR=1.126，95%CI 1.026-1.236，P=0.012；显性模型：OR=1.172，95%CI 1.024-1.341，P=0.021；纯合子模型：OR=1.213，95%CI 1.038-1.417，P=0.015；等位基因模型：OR=1.109，95%CI 1.025-1.200，P=0.010）。按地区进行的亚组分析显示，我们的发现表明欧洲存在显著关联，但中东地区则无关联。
本荟萃分析表明，IL7R T244I 多态性的 C 等位基因可能是欧洲 MS 易感性的一个危险因素，但不是中东地区的危险因素。
