Division of Endocrinology and Molecular Medicine, University of Kentucky, Wethington Building, Room 567, 900 South Limestone Street, Lexington, KY 40536-0200, USA.
Curr Diab Rep. 2011 Apr;11(2):77-82. doi: 10.1007/s11892-010-0167-6.
The use of U-500 insulin in the management of highly insulin resistant diabetic patients is growing. There are a number of reports that have noted the effects of U-500 insulin using multiple daily injections or continuous subcutaneous insulin infusion on hemoglobin A(1c), weight, and total daily insulin dosage. The effect of U-500 insulin use on glycemic control, changes in body weight, total daily insulin dosage, incidence of hypoglycemia, and effect on lipid levels and blood pressure as well as patient satisfaction and quality of life will be reviewed. In addition, this article will delineate algorithms of U-500 use, compare multiple daily injections or continuous subcutaneous insulin infusion, and discuss U-500 insulin pharmacokinetics.
U-500 胰岛素在治疗高度胰岛素抵抗的糖尿病患者中的应用正在增加。有许多报告指出，U-500 胰岛素多次注射或持续皮下胰岛素输注对糖化血红蛋白（HbA1c）、体重和总日剂量的影响。本文将回顾 U-500 胰岛素使用对血糖控制、体重变化、总日剂量、低血糖发生率以及对血脂水平和血压的影响，以及患者的满意度和生活质量。此外，本文还将阐述 U-500 使用的算法，比较多次注射或持续皮下胰岛素输注，并讨论 U-500 胰岛素药代动力学。
