Division of General Surgery, Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Room S4B, Baltimore, MD 21201, USA.
Obes Surg. 2011 May;21(5):655-62. doi: 10.1007/s11695-010-0325-6.
To minimize morbidity and mortality associated with surgery risks in the obese patient, algorithms offer planning operative strategy. Because these algorithms often classify patients based on inadequate category granularity, outcomes may not be predicted accurately. We reviewed patient factors and patient outcomes for those who had undergone bariatric surgical procedures to determine relationships and developed a nomogram to calculate individualized patient risk.
From the American College of Surgeons National Security Quality Improvement Program database, we identified 32,426 bariatric surgery patients meeting NIH criteria and treated between 2005 and 2008. We defined a composite binary outcome of 30-day postoperative morbidity and mortality. A predictive model based on preoperative variables was developed using multivariable logistic regression; a multiple imputation procedure allowed inclusions of observations with missing data. Model performance was assessed using the C-statistic. A calibration plot graphically assessed the agreement between predicted and observed probabilities in regard to 30-day morbidity/mortality.
The nomogram model was constructed for maximal predictive accuracy. The estimated C-statistic [95% confidence interval] for the predictive nomogram was 0.629 [0.614, 0.645], indicative of slight to moderate discriminative ability beyond that of chance alone, and the greatest impacts on the estimated probability of morbidity/mortality were determined to be age, body mass index, serum albumin, and functional status.
By accurately predicting 30-day morbidity and mortality, this nomogram may prove useful in patient preoperative counseling on postoperative complication risk. Our results additionally indicate that neither age nor presence of obesity-related comorbidities should exclude patients from bariatric surgery consideration.
为了最大限度地降低肥胖患者手术风险相关的发病率和死亡率,算法提供了规划手术策略的方案。由于这些算法通常基于不充分的分类粒度对患者进行分类,因此可能无法准确预测结果。我们回顾了接受减重手术的患者的因素和结果,以确定它们之间的关系,并开发了一个列线图来计算个体患者的风险。
我们从美国外科医师学会国家手术质量改进计划数据库中确定了符合 NIH 标准并于 2005 年至 2008 年间接受治疗的 32426 例减重手术患者。我们定义了 30 天术后发病率和死亡率的复合二项结局。使用多变量逻辑回归开发了基于术前变量的预测模型;通过多重插补程序可以包含缺失数据的观察值。使用 C 统计量评估模型性能。校准图以图形方式评估了 30 天发病率/死亡率的预测概率与观察概率之间的一致性。
为了获得最大的预测准确性,构建了列线图模型。预测列线图的估计 C 统计量[95%置信区间]为 0.629[0.614,0.645],表明其具有轻微到中度的判别能力,超出了单纯机会的范围,对发病率/死亡率的估计概率影响最大的因素是年龄、体重指数、血清白蛋白和功能状态。
通过准确预测 30 天的发病率和死亡率,该列线图可能有助于患者术前咨询术后并发症风险。我们的结果还表明,年龄或肥胖相关合并症的存在都不应排除患者接受减重手术的考虑。