Division of Rheumatology, University of Florida, 1600 Southwest Archer Road, Room 4102, Gainesville, FL 32610-0277, USA.
Curr Rheumatol Rep. 2011 Apr;13(2):154-9. doi: 10.1007/s11926-010-0154-6.
Gout is a common inflammatory arthritis. We know a great deal about its etiopathogenesis and have relatively safe and effective therapies for it. Gout, however, remains a poorly managed disease with mistakes made in securing an accurate diagnosis and in using appropriate therapies for acute and chronic stages of the disease. Synovial fluid analysis with polarizing microscopy is the "gold standard" for confirming the diagnosis of gout but has been used in fewer than 10% of all patients diagnosed with gout. The newly adopted European clinical guidelines offer a practical alternative to synovial fluid analysis, but primary care physicians are not well-versed in their use. Other serious errors in the management of gout are related to the use of medications to treat acute and chronic gout. Frequently, the anti-inflammatory drugs used to treat acute symptoms and urate-lowering drugs used to prevent long-term destruction are improperly dosed, leading to dissatisfaction on the part of patients and physicians. Widespread education about evidence-based diagnostic and treatment guidelines is desperately needed.
痛风是一种常见的炎性关节炎。我们对其发病机制有了深入的了解,并有相对安全有效的治疗方法。然而,痛风仍然是一种管理不善的疾病,在确诊和使用急性及慢性阶段的适当治疗方面存在错误。关节液分析结合偏光显微镜检查是确诊痛风的“金标准”,但在所有确诊痛风的患者中,该检查的使用率不足 10%。新采用的欧洲临床指南为关节液分析提供了一种实用的替代方法,但初级保健医生对此并不熟悉。痛风管理中的其他严重错误与用于治疗急性和慢性痛风的药物有关。通常,用于治疗急性症状的抗炎药和用于预防长期破坏的降尿酸药剂量不当,导致患者和医生都不满意。迫切需要开展广泛的基于证据的诊断和治疗指南教育。