哺乳期硫代苹果酸金钠的使用。
Use of sodium aurothiomalate during lactation.
作者信息
Bennett P N, Humphries S J, Osborne J P, Clarke A K, Taylor A
机构信息
Clinical Pharmacology Unit, Royal United Hospital, Bath, Avon.
出版信息
Br J Clin Pharmacol. 1990 Jun;29(6):777-9. doi: 10.1111/j.1365-2125.1990.tb03703.x.
The report concerns a mother who breast fed her infant whilst receiving sodium aurothiomalate for the treatment of rheumatoid arthritis. The milk:serum concentration ratio was not constant, reflecting the non-concurrence of the concentration-time profiles of gold in milk and maternal serum after i.m. injection. Gold was detected in the infant's serum. Calculations indicate that the weight-adjusted dose to the infant exceeded that received by the mother.
该报告涉及一名在接受硫代苹果酸金钠治疗类风湿性关节炎期间母乳喂养婴儿的母亲。乳汁与血清的浓度比并不恒定，这反映了肌肉注射后乳汁和母体血清中金的浓度-时间曲线不一致。在婴儿血清中检测到了金。计算表明，按体重调整后婴儿摄入的剂量超过了母亲的摄入量。
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