Egila J, Littlejohn D, Smith W E, Sturrock R D
Department of Chemistry, Federal University of Technology, Yola, Nigeria.
J Pharm Biomed Anal. 1992 Sep;10(9):639-44. doi: 10.1016/0731-7085(92)80091-z.
Gold levels in the plasma and blood cells of patients treated with the gold drug Myocrisin (sodium aurothiomalate) were determined by atomic absorption spectrometry. There is a correlation between whole blood gold and plasma gold concentrations which is different for smokers and non-smokers. Most cellular gold is associated with the membrane and is present in concentrations approximately equivalent to the number of reactive sulphydryl groups on the exofacial surface of the cell. Since gold would be expected to react with SH groups and since these groups are vital for cellular function, a possible role for gold in modifying cellular metabolism is indicated.
采用原子吸收光谱法测定了接受金制剂米奥克立明（硫代苹果酸金钠）治疗的患者血浆和血细胞中的金含量。全血金浓度与血浆金浓度之间存在相关性，吸烟者和非吸烟者的这种相关性有所不同。大多数细胞内金与细胞膜相关，其浓度大约与细胞外表面活性巯基的数量相当。由于预计金会与巯基发生反应，且这些基团对细胞功能至关重要，因此表明金在改变细胞代谢方面可能发挥作用。
