接受金疗法的类风湿患者血浆各组分中金的分布情况，与硫代苹果酸金钠体外孵育血浆中金的分布情况相比较。
Distribution of gold among plasma fractions in rheumatoid patients undergoing chrysotherapy compared with its distribution in plasma incubated with aurothiomalate in vitro.
作者信息
Danpure C J, Fyfe D A, Gumpel J M
出版信息
Ann Rheum Dis. 1979 Aug;38(4):364-70. doi: 10.1136/ard.38.4.364.
Abstract
The distribution of gold among the globulin, albumin, and unbound fractions of plasma, obtained either from rheumatoid patients receiving long-term aurothiomalate therapy or from samples incubated with aurothiomalate in vitro, has been investigated. In the rheumatoid patients it has been found that, although the majority of the plasma gold is always bound to albumin, the distribution varies cyclically in phase with the dose schedule. An explanation of these phenomena is provided, based on data obtained from the reaction between aurothiomalate and plasma constituents in vitro.
摘要
对从接受长期金硫代苹果酸治疗的类风湿患者身上获取的血浆，或在体外与金硫代苹果酸一起孵育的样本中，金在球蛋白、白蛋白和未结合部分之间的分布情况进行了研究。在类风湿患者中发现，虽然大部分血浆金始终与白蛋白结合，但分布会随剂量方案呈周期性变化。基于体外金硫代苹果酸与血浆成分反应获得的数据，对这些现象给出了解释。
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